STOP — Contraindicated
FDA Black Box Warning — avoid concurrent prescribing. If no alternative exists, use minimum effective doses.
Evidence level: STRONG
Combining oxycodone with lorazepam can be fatal. Both drugs depress your central nervous system and slow breathing. The FDA Black Box Warning states this combination has caused deaths.
Combined CNS depression: opioid mu-receptor agonism plus GABA-A receptor potentiation. FDA Black Box Warning.
These medications should not be taken together unless your doctor has determined the benefits outweigh the serious risks. Never share or combine leftover prescriptions.
Take Lorazepam only as prescribed — benzodiazepines carry dependence risk and should not be adjusted without medical guidance. Oxycodone at a separate time. Benzodiazepines cause sedation — avoid combining with other sedating substances. Never increase dose without medical guidance.
Risk increases with higher doses of either substance, older age, liver or kidney impairment, and concurrent use of other serotonergic or CNS-depressant substances.
Extreme sedation, dangerously slow breathing, bluish lips or nail beds, unresponsiveness, coma
Ask about tapering off one medication. Discuss whether your pain or anxiety can be managed with safer alternatives.
Opioid combinations carry serious risks including respiratory depression. Talk to your pain management specialist about non-opioid alternatives: physical therapy, NSAIDs (if appropriate), nerve blocks, or non-sedating supplements like PEA (palmitoylethanolamide) or curcumin for inflammation.
Combining oxycodone with lorazepam can be fatal. Both drugs depress your central nervous system and slow breathing. The FDA Black Box Warning states this combination has caused deaths.
Take Lorazepam only as prescribed — benzodiazepines carry dependence risk and should not be adjusted without medical guidance. Oxycodone at a separate time. Benzodiazepines cause sedation — avoid combining with other sedating substances. Never increase dose without medical guidance.
Extreme sedation, dangerously slow breathing, bluish lips or nail beds, unresponsiveness, coma
Opioid combinations carry serious risks including respiratory depression. Talk to your pain management specialist about non-opioid alternatives: physical therapy, NSAIDs (if appropriate), nerve blocks, or non-sedating supplements like PEA (palmitoylethanolamide) or curcumin for inflammation.
Ask about tapering off one medication. Discuss whether your pain or anxiety can be managed with safer alternatives.
Or browse the full interaction database (121,000+ pairs).