STOP — Contraindicated
CONTRAINDICATED — dual full opioid agonists
Evidence level: STRONG
Combining methadone with oxycodone creates extreme overdose risk.
Two full opioid agonists: extreme additive respiratory depression.
Never combine without specialist supervision.
Two opioids together requires extremely careful medical supervision. Take each exactly at prescribed times — set alarms if needed. Never take extra doses. Cumulative respiratory depression risk is significant. Keep naloxone (Narcan) accessible and ensure someone in your household knows how to use it.
Methadone accumulation, concurrent CNS depressants
Respiratory arrest, extreme sedation, death
Requires addiction medicine or pain specialist coordination.
Opioid combinations carry serious risks including respiratory depression. Talk to your pain management specialist about non-opioid alternatives: physical therapy, NSAIDs (if appropriate), nerve blocks, or non-sedating supplements like PEA (palmitoylethanolamide) or curcumin for inflammation.
Combining methadone with oxycodone creates extreme overdose risk.
Two opioids together requires extremely careful medical supervision. Take each exactly at prescribed times — set alarms if needed. Never take extra doses. Cumulative respiratory depression risk is significant. Keep naloxone (Narcan) accessible and ensure someone in your household knows how to use it.
Respiratory arrest, extreme sedation, death
Opioid combinations carry serious risks including respiratory depression. Talk to your pain management specialist about non-opioid alternatives: physical therapy, NSAIDs (if appropriate), nerve blocks, or non-sedating supplements like PEA (palmitoylethanolamide) or curcumin for inflammation.
Requires addiction medicine or pain specialist coordination.
Or browse the full interaction database (121,000+ pairs).