MAJOR — Use With Caution
FDA atomoxetine label warns about strong CYP2D6 inhibitors. Dose adjustment needed. Atomoxetine levels can increase several-fold.
Evidence level: STRONG
Prozac can dramatically increase atomoxetine (Strattera) levels by blocking the enzyme that metabolizes it. This can cause increased heart rate, high blood pressure, and other side effects.
Fluoxetine is a potent CYP2D6 inhibitor. Atomoxetine is primarily metabolized by CYP2D6. Co-administration increases atomoxetine levels significantly. FDA atomoxetine label warns about CYP2D6 inhibitors.
If taking both, your Strattera dose may need to be lower. Report any racing heart, elevated blood pressure, or increased anxiety to your doctor.
Take Fluoxetine at the same time each day — morning is most common to avoid sleep disruption. Atomoxetine follows its prescribed schedule. SSRIs have a long half-life, so consistency matters more than the exact hour.
Higher risk for: elderly, those on multiple serotonergic drugs, people with liver impairment, CYP2D6 poor metabolizers, recent dose changes, or concurrent use of MAOIs or triptans.
Increased heart rate, high blood pressure, nausea, decreased appetite, insomnia, dizziness, mood changes
Start atomoxetine at lower dose with strong CYP2D6 inhibitors. Monitor heart rate and blood pressure. Consider whether SSRI or atomoxetine alone could address both conditions.
Discuss this combination with your prescriber. They may adjust timing, dosing, or switch to an alternative with fewer interaction risks. Never stop an antidepressant abruptly — taper under medical guidance.
Prozac can dramatically increase atomoxetine (Strattera) levels by blocking the enzyme that metabolizes it. This can cause increased heart rate, high blood pressure, and other side effects.
Take Fluoxetine at the same time each day — morning is most common to avoid sleep disruption. Atomoxetine follows its prescribed schedule. SSRIs have a long half-life, so consistency matters more than the exact hour.
Increased heart rate, high blood pressure, nausea, decreased appetite, insomnia, dizziness, mood changes
Discuss this combination with your prescriber. They may adjust timing, dosing, or switch to an alternative with fewer interaction risks. Never stop an antidepressant abruptly — taper under medical guidance.
Start atomoxetine at lower dose with strong CYP2D6 inhibitors. Monitor heart rate and blood pressure. Consider whether SSRI or atomoxetine alone could address both conditions.
Or browse the full interaction database (121,000+ pairs).