MAJOR — Use With Caution
FDA aripiprazole label — reduce dose by 50% with strong CYP2D6 inhibitors (fluoxetine, paroxetine).
Evidence level: STRONG
Prozac can increase aripiprazole (Abilify) levels by blocking the enzyme that metabolizes it. The FDA recommends cutting the Abilify dose in half when taking it with Prozac.
Fluoxetine is a potent CYP2D6 inhibitor. Aripiprazole is partially metabolized by CYP2D6. FDA aripiprazole label recommends dose reduction to 50% of usual dose with strong CYP2D6 inhibitors.
If you take both medications, your Abilify dose should be half of what it would normally be. Tell your doctor about both medications.
Take Fluoxetine at the same time each day — morning is most common to avoid sleep disruption. Aripiprazole follows its prescribed schedule. SSRIs have a long half-life, so consistency matters more than the exact hour.
Higher risk for: elderly, those on multiple serotonergic drugs, people with liver impairment, CYP2D6 poor metabolizers, recent dose changes, or concurrent use of MAOIs or triptans.
Excessive drowsiness, restlessness (akathisia), tremor, dizziness, nausea
Reduce aripiprazole dose by 50% with fluoxetine. Applies to paroxetine as well. Adjust back if CYP2D6 inhibitor is stopped.
Discuss this combination with your prescriber. They may adjust timing, dosing, or switch to an alternative with fewer interaction risks. Never stop an antidepressant abruptly — taper under medical guidance.
Prozac can increase aripiprazole (Abilify) levels by blocking the enzyme that metabolizes it. The FDA recommends cutting the Abilify dose in half when taking it with Prozac.
Take Fluoxetine at the same time each day — morning is most common to avoid sleep disruption. Aripiprazole follows its prescribed schedule. SSRIs have a long half-life, so consistency matters more than the exact hour.
Excessive drowsiness, restlessness (akathisia), tremor, dizziness, nausea
Discuss this combination with your prescriber. They may adjust timing, dosing, or switch to an alternative with fewer interaction risks. Never stop an antidepressant abruptly — taper under medical guidance.
Reduce aripiprazole dose by 50% with fluoxetine. Applies to paroxetine as well. Adjust back if CYP2D6 inhibitor is stopped.
Or browse the full interaction database (121,000+ pairs).