STOP — Contraindicated
FDA contraindication. 5-week washout period required after stopping fluoxetine before starting rasagiline, due to fluoxetine long half-life.
Evidence level: STRONG
Prozac and rasagiline must never be taken together — the combination can cause life-threatening serotonin syndrome. Because Prozac stays in your system for weeks, you must wait at least 5 weeks after stopping Prozac before starting rasagiline.
Rasagiline (irreversible MAO-B inhibitor) plus fluoxetine (SSRI). FDA contraindication. Requires 5-week washout after fluoxetine discontinuation before starting rasagiline.
If you are switching from Prozac to rasagiline, your doctor must plan a 5-week washout. Do not start rasagiline sooner. This is longer than other SSRIs because Prozac stays in your body longer.
Take Fluoxetine at the same time each day — morning is most common to avoid sleep disruption. Rasagiline follows its prescribed schedule. SSRIs have a long half-life, so consistency matters more than the exact hour.
Higher risk for: elderly, those on multiple serotonergic drugs, people with liver impairment, CYP2D6 poor metabolizers, recent dose changes, or concurrent use of MAOIs or triptans.
Severe agitation, dangerously high fever, seizures, muscle rigidity, unstable blood pressure, coma
Emphasize the 5-week washout requirement. Discuss whether a shorter-acting SSRI should be used first to shorten transition time.
Discuss this combination with your prescriber. They may adjust timing, dosing, or switch to an alternative with fewer interaction risks. Never stop an antidepressant abruptly — taper under medical guidance.
Prozac and rasagiline must never be taken together — the combination can cause life-threatening serotonin syndrome. Because Prozac stays in your system for weeks, you must wait at least 5 weeks after stopping Prozac before starting rasagiline.
Take Fluoxetine at the same time each day — morning is most common to avoid sleep disruption. Rasagiline follows its prescribed schedule. SSRIs have a long half-life, so consistency matters more than the exact hour.
Severe agitation, dangerously high fever, seizures, muscle rigidity, unstable blood pressure, coma
Discuss this combination with your prescriber. They may adjust timing, dosing, or switch to an alternative with fewer interaction risks. Never stop an antidepressant abruptly — taper under medical guidance.
Emphasize the 5-week washout requirement. Discuss whether a shorter-acting SSRI should be used first to shorten transition time.
Or browse the full interaction database (121,000+ pairs).