STOP — Contraindicated
FDA contraindication with 5-week washout requirement after fluoxetine discontinuation.
Evidence level: STRONG
Selegiline and Prozac together can cause fatal serotonin syndrome. A 5-week waiting period is needed after stopping Prozac before starting selegiline because Prozac takes that long to leave your body.
Selegiline (MAO-B inhibitor) plus fluoxetine (SSRI). FDA contraindication. 5-week washout required after fluoxetine due to long half-life.
Wait at least 5 weeks after your last Prozac dose before starting selegiline. This is not optional — it is a safety requirement.
Take Fluoxetine at the same time each day — morning is most common to avoid sleep disruption. Selegiline follows its prescribed schedule. SSRIs have a long half-life, so consistency matters more than the exact hour.
Higher risk for: elderly, those on multiple serotonergic drugs, people with liver impairment, CYP2D6 poor metabolizers, recent dose changes, or concurrent use of MAOIs or triptans.
Severe agitation, high fever, seizures, muscle stiffness, rapid heartbeat, blood pressure crisis, coma
Plan the 5-week washout carefully. Consider switching to a shorter-acting SSRI first if time is a factor. Ensure both prescribers coordinate.
Discuss this combination with your prescriber. They may adjust timing, dosing, or switch to an alternative with fewer interaction risks. Never stop an antidepressant abruptly — taper under medical guidance.
Selegiline and Prozac together can cause fatal serotonin syndrome. A 5-week waiting period is needed after stopping Prozac before starting selegiline because Prozac takes that long to leave your body.
Take Fluoxetine at the same time each day — morning is most common to avoid sleep disruption. Selegiline follows its prescribed schedule. SSRIs have a long half-life, so consistency matters more than the exact hour.
Severe agitation, high fever, seizures, muscle stiffness, rapid heartbeat, blood pressure crisis, coma
Discuss this combination with your prescriber. They may adjust timing, dosing, or switch to an alternative with fewer interaction risks. Never stop an antidepressant abruptly — taper under medical guidance.
Plan the 5-week washout carefully. Consider switching to a shorter-acting SSRI first if time is a factor. Ensure both prescribers coordinate.
Or browse the full interaction database (121,000+ pairs).