# Roseburia intestinalis

**Canonical URL:** https://ingredients.hermeticasuperfoods.com/ingredients/roseburia-intestinalis
**Data Source:** Hermetica Superfoods Ingredient Encyclopedia
**Updated:** 2026-03-18
**Evidence Score:** 4 / 10
**Category:** Fermented/Probiotic
**Also Known As:** Roseburia intestinalis, R. intestinalis, Butyrate-producing bacterium, Intestinal Roseburia, Roseburia sp., Gut commensal bacteria, Anti-inflammatory probiotic

## Overview

Roseburia intestinalis is a next-generation probiotic bacterium that produces butyrate through fermentation of dietary fiber in the colon. This butyrate production supports intestinal barrier function, reduces [inflammation](/ingredients/condition/inflammation), and promotes optimal [digestive health](/ingredients/condition/gut-health).

## Health Benefits

- Produces butyrate, promoting colon health and reducing inflammation, which is vital for digestive comfort. - Supports [digestion](/ingredients/condition/gut-health) by breaking down complex carbohydrates, enhancing nutrient absorption and energy levels. - Enhances [immune function](/ingredients/condition/immune-support) by increasing the production of [anti-inflammatory](/ingredients/condition/inflammation) cytokines, reducing the risk of infections. - Promotes mental well-being by influencing the gut-brain axis, potentially alleviating anxiety and depression. - Aids in weight management by regulating fat storage and energy expenditure, supporting a healthy body weight. - Improves [skin health](/ingredients/condition/skin-health) by reducing systemic inflammation, which can alleviate conditions like acne and eczema. - Supports [cardiovascular health](/ingredients/condition/heart-health) by reducing cholesterol levels, lowering the risk of heart disease.

## Mechanism of Action

Roseburia intestinalis ferments complex carbohydrates and resistant starches through butyrate-CoA transferase pathways, producing short-chain fatty acids, particularly butyrate. Butyrate activates GPR43 and GPR109A receptors on colonocytes, strengthening tight junctions and reducing NF-κB [inflammatory](/ingredients/condition/inflammation) signaling. This mechanism enhances [intestinal barrier integrity](/ingredients/condition/gut-health) while promoting regulatory [T-cell](/ingredients/condition/immune-support) differentiation through histone deacetylase inhibition.

## Clinical Summary

Research on Roseburia intestinalis primarily consists of observational studies and in vitro experiments rather than randomized controlled trials. Studies show depleted levels in [inflammatory](/ingredients/condition/inflammation) bowel disease patients and metabolic disorders, with butyrate concentrations reaching 10-20 mM in healthy individuals. Small pilot studies suggest supplementation may increase fecal butyrate levels by 2-3 fold within 2-4 weeks. Evidence remains preliminary, requiring larger clinical trials to establish therapeutic efficacy and optimal dosing protocols.

## Nutritional Profile

- Produces butyrate and other short-chain fatty acids. - Contains enzymes that degrade complex carbohydrates. - Rich in polysaccharides beneficial for gut health.

## Dosage & Preparation

There is no standardized dosage for Roseburia intestinalis supplements. Consult a healthcare provider before use.

## Safety & Drug Interactions

Roseburia intestinalis appears generally safe for healthy individuals, though comprehensive safety data is limited due to its recent classification as a next-generation [probiotic](/ingredients/condition/gut-health). Mild gastrointestinal symptoms including bloating or gas may occur during initial colonization. No significant drug interactions are currently documented, but caution is advised with immunosuppressive medications. Safety during pregnancy and lactation has not been established, requiring medical supervision for use in these populations.

## Scientific Research

Research on Roseburia intestinalis includes in vitro studies and animal models, with growing interest in its role in gut health and metabolic regulation. Human trials are limited but promising.

## Historical & Cultural Context

Identified in the late 20th century, Roseburia intestinalis has gained attention for its role in maintaining gut health and its potential therapeutic applications.

## Synergistic Combinations

[Prebiotic](/ingredients/condition/gut-health) Fiber,Polyphenols,Omega-3 Fatty Acids

## Frequently Asked Questions

### How much butyrate does Roseburia intestinalis produce?

Roseburia intestinalis can produce 10-20 mM concentrations of butyrate in the colon through fiber fermentation. This represents approximately 60-70% of total short-chain fatty acid production in healthy individuals.

### What foods help Roseburia intestinalis grow?

Roseburia intestinalis thrives on resistant starch, inulin, and pectin found in foods like cooked and cooled potatoes, green bananas, and Jerusalem artichokes. These prebiotic fibers provide the substrate needed for butyrate production.

### Can Roseburia intestinalis help with IBD?

Studies show significantly reduced Roseburia intestinalis levels in IBD patients compared to healthy controls. While preliminary research suggests supplementation may help restore butyrate production, clinical trials are needed to confirm therapeutic benefits.

### How long does it take for Roseburia intestinalis to colonize?

Initial colonization typically occurs within 7-14 days of supplementation, with peak butyrate production achieved after 2-4 weeks. Sustained colonization requires continued prebiotic fiber intake to maintain bacterial populations.

### What's the difference between Roseburia intestinalis and other probiotics?

Unlike traditional probiotics like Lactobacillus, Roseburia intestinalis is an obligate anaerobe that specifically produces butyrate rather than lactic acid. It targets colon health through SCFA production rather than small intestine acidification.

### Is Roseburia intestinalis safe for people with IBS or sensitive digestive systems?

Roseburia intestinalis is generally well-tolerated and may actually benefit IBS sufferers due to its butyrate production, which supports colon health and reduces inflammation. However, some individuals may experience temporary bloating or gas during initial colonization as the bacteria establish themselves. It's recommended to start with lower amounts and gradually increase to allow your digestive system to adapt, and consult a healthcare provider if you have severe IBS or are immunocompromised.

### Can Roseburia intestinalis supplementation interact with antibiotics or other medications?

Roseburia intestinalis can be significantly impacted by broad-spectrum antibiotics, which may kill or reduce the probiotic bacteria before it establishes in your gut. If you're taking antibiotics, space probiotic supplements at least 2-3 hours apart from medication doses and consider waiting until after your antibiotic course to begin supplementation. There are no known direct interactions with non-antibiotic medications, but those with compromised immune systems should consult their healthcare provider before use.

### What clinical evidence supports Roseburia intestinalis for gut-brain health and mood?

Research shows that Roseburia intestinalis influences the gut-brain axis by producing butyrate, which supports the production of anti-inflammatory cytokines and may enhance neurotransmitter regulation linked to mood and anxiety. Several studies have demonstrated associations between low levels of Roseburia species and conditions like depression and anxiety, though research is still emerging. While promising, most evidence is observational or preclinical, so Roseburia supplementation should be considered as part of a comprehensive approach to mental wellness rather than a standalone treatment.

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*Source: Hermetica Superfoods Ingredient Encyclopedia — https://ingredients.hermeticasuperfoods.com*
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