Probiotic & Fiber · Fermented/Probiotic

Roseburia intestinalis

Provisional Moderate Scoreprobiotic

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Roseburia intestinalis is a next-generation probiotic bacterium that produces butyrate through fermentation of dietary fiber in the colon. This butyrate production supports intestinal barrier function, reduces inflammation, and promotes optimal digestive health.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryProbiotic & Fiber

GroupFermented/Probiotic

Public Score StatusProvisional Moderate

Primary KeywordRoseburia intestinalis benefits

Roseburia intestinalis close-up macro showing natural texture and detail — rich in short-chain fatty acid producer, anti-inflammatory, gut barrier support

Roseburia intestinalis — botanical close-up

Reported Benefits (Provisional)

Produces butyrate, promoting colon health and reducing inflammation, which is vital for digestive comfort. - Supports digestion by breaking down complex carbohydrates, enhancing nutrient absorption and energy levels. - Enhances immune function by increasing the production of anti-inflammatory cytokines, reducing the risk of infections. - Promotes mental well-being by influencing the gut-brain axis, potentially alleviating anxiety and depression. - Aids in weight management by regulating fat storage and energy expenditure, supporting a healthy body weight. - Improves skin health by reducing systemic inflammation, which can alleviate conditions like acne and eczema. - Supports cardiovascular health by reducing cholesterol levels, lowering the risk of heart disease.

Origin & History

Natural habitat

Roseburia intestinalis is a gram-positive, anaerobic bacterium prevalent in the human gut. It is cultured under anaerobic conditions due to its oxygen sensitivity, often isolated from fecal samples for research purposes.

“Identified in the late 20th century, Roseburia intestinalis has gained attention for its role in maintaining gut health and its potential therapeutic applications.”Traditional Medicine

Research Narrative (Provisional)

Research on Roseburia intestinalis includes in vitro studies and animal models, with growing interest in its role in gut health and metabolic regulation. Human trials are limited but promising.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Produces butyrate and other short-chain fatty acids. - Contains enzymes that degrade complex carbohydrates. - Rich in polysaccharides beneficial for gut health.

Reported Mechanism (Provisional)

Mechanism of Action

Roseburia intestinalis ferments complex carbohydrates and resistant starches through butyrate-CoA transferase pathways, producing short-chain fatty acids, particularly butyrate. Butyrate activates GPR43 and GPR109A receptors on colonocytes, strengthening tight junctions and reducing NF-κB inflammatory signaling. This mechanism enhances intestinal barrier integrity while promoting regulatory T-cell differentiation through histone deacetylase inhibition.

Clinical Narrative (Provisional)

Research on Roseburia intestinalis primarily consists of observational studies and in vitro experiments rather than randomized controlled trials. Studies show depleted levels in inflammatory bowel disease patients and metabolic disorders, with butyrate concentrations reaching 10-20 mM in healthy individuals. Small pilot studies suggest supplementation may increase fecal butyrate levels by 2-3 fold within 2-4 weeks. Evidence remains preliminary, requiring larger clinical trials to establish therapeutic efficacy and optimal dosing protocols.

Also Known As

Roseburia intestinalisR. intestinalisButyrate-producing bacteriumIntestinal RoseburiaRoseburia sp.Gut commensal bacteriaAnti-inflammatory probiotic

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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