Hermetica Superfood Encyclopedia
The Short Answer
Bifidobacterium infantis 35624 is a clinically studied probiotic strain that modulates gut microbiota through production of short-chain fatty acids and antimicrobial compounds. This strain specifically reduces inflammatory cytokines and enhances intestinal barrier function to improve digestive health and IBS symptoms.
CategoryProbiotic & Fiber
GroupFermented/Probiotic
Evidence LevelStrong
Primary KeywordBifidobacterium infantis 35624 benefits
Synergy Pairings5
Bifidobacterium infantis 35624 — botanical close-up
Health Benefits
Supports digestive health by balancing gut microbiota, enhancing nutrient absorption and reducing bloating. - May reduce symptoms of irritable bowel syndrome by 50%, improving quality of life. - Boosts immune function by increasing production of protective antibodies. - Enhances mental health by producing neurotransmitters like serotonin. - Reduces inflammation by modulating cytokine production, leading to less discomfort. - Improves skin health by reducing systemic inflammation, promoting a clearer complexion. - Aids in weight management by influencing hormones that regulate appetite.
Origin & History
Natural habitat
Bifidobacterium infantis 35624 is a specific strain of probiotic bacteria isolated from the human gastrointestinal tract. It is cultivated under controlled conditions to ensure purity and efficacy. This strain is often used in supplements for its gut health benefits.
“Bifidobacterium species have been used in fermented foods for centuries. Their discovery in the early 20th century revolutionized the understanding of gut microbiota.”Traditional Medicine
Scientific Research
Several randomized controlled trials (RCTs) have demonstrated the efficacy of Bifidobacterium infantis 35624 in managing IBS symptoms. Meta-analyses support its role in enhancing gut health and immune function.
Preparation & Dosage
Traditional preparation
Typical dosage ranges from 1-10 billion CFUs daily in capsule or powder form. Consult a healthcare provider before use.
Nutritional Profile
- Contains live beneficial bacteria.
- Supports production of short-chain fatty acids.
- Contributes to maintaining a healthy gut flora balance.
How It Works
Mechanism of Action
B. infantis 35624 produces acetate, propionate, and butyrate short-chain fatty acids that strengthen tight junctions in the intestinal epithelium and reduce pro-inflammatory cytokines IL-6 and TNF-α. The strain synthesizes bacteriocins that inhibit pathogenic bacteria while stimulating regulatory T-cells through Toll-like receptor 2 signaling. It also increases secretory IgA production and enhances mucin secretion by goblet cells.
Clinical Evidence
Multiple randomized controlled trials with 362 IBS patients demonstrated 50% reduction in abdominal pain, bloating, and bowel movement difficulty over 4-8 weeks. A placebo-controlled study of 75 participants showed significant improvements in inflammatory markers including reduced IL-10 and increased anti-inflammatory cytokines. Clinical evidence is robust with consistent outcomes across studies, though most trials were conducted on adults with IBS rather than broader populations.
Safety & Interactions
B. infantis 35624 is generally well-tolerated with mild gastrointestinal side effects like temporary gas or bloating in less than 5% of users. No significant drug interactions have been reported, though it may theoretically reduce effectiveness of antibiotics if taken simultaneously. Immunocompromised individuals should consult healthcare providers before use due to theoretical risk of bacteremia. Safety during pregnancy and lactation has not been specifically studied, warranting caution in these populations.
Synergy Stack
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Also Known As
Bifidobacterium longum subsp. infantis 35624B. infantis 35624BifantisAlign probiotic strain35624 strainInfant bifidobacteria
Frequently Asked Questions
How long does Bifidobacterium infantis 35624 take to work for IBS?
Clinical studies show significant IBS symptom improvement within 4 weeks of daily supplementation with B. infantis 35624. Maximum benefits typically occur after 8 weeks of consistent use at therapeutic doses of 1 billion CFU daily.
What is the recommended dosage of Bifidobacterium infantis 35624?
The clinically effective dose is 1 billion CFU (colony forming units) taken once daily, preferably with food. This dosage was used in most clinical trials demonstrating IBS symptom reduction and digestive health benefits.
Can Bifidobacterium infantis 35624 be taken with antibiotics?
It's recommended to separate B. infantis 35624 from antibiotics by at least 2-3 hours to prevent antibiotic destruction of the probiotic bacteria. Taking probiotics during and after antibiotic treatment may help restore beneficial gut bacteria.
Does Bifidobacterium infantis 35624 need refrigeration?
Most commercial B. infantis 35624 supplements are freeze-dried and shelf-stable at room temperature for 12-24 months. However, refrigeration can extend potency and maintain higher viable bacterial counts throughout the product's lifespan.
Is Bifidobacterium infantis 35624 safe for children?
While B. infantis is naturally found in infant gut microbiomes, specific safety data for the 35624 strain in children is limited. Most clinical studies were conducted in adults, so pediatric use should be supervised by a healthcare provider.
What clinical research supports Bifidobacterium infantis 35624 for IBS symptoms?
Multiple randomized controlled trials have demonstrated that Bifidobacterium infantis 35624 (marketed as Align) reduces IBS symptom severity by approximately 50% compared to placebo, with improvements in abdominal pain, bloating, and bowel dysfunction. The most notable study published in the American Journal of Gastroenterology showed significant benefits after 4 weeks of consistent use, with effects sustained over 8 weeks of treatment. Research indicates this strain is one of the most well-studied probiotics for IBS, with evidence supporting its efficacy in both men and women.
Does Bifidobacterium infantis 35624 help with bloating and gas specifically?
Yes, Bifidobacterium infantis 35624 is particularly effective at reducing bloating and gas by promoting the growth of beneficial bacteria that produce fewer fermentation byproducts and improve intestinal gas clearance. Clinical studies show this strain reduces abdominal distension within 2-4 weeks of daily use by modulating gut microbiota composition and reducing pathogenic bacteria that cause excessive gas production. This makes it especially beneficial for individuals with IBS-D or IBS-M who experience prominent bloating symptoms.
Who should avoid Bifidobacterium infantis 35624?
Individuals with severe immunocompromise (such as those with HIV/AIDS, organ transplant recipients, or those on immunosuppressive medications) should consult a healthcare provider before use, as live probiotics may pose a theoretical risk. People with histamine intolerance may experience adverse reactions, as some probiotic strains can increase histamine levels. Additionally, those with a documented allergy to any ingredient in the formulation or a history of adverse reactions to probiotics should avoid this supplement.
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