Hermetica Superfood Encyclopedia
Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.
Review flags: AWAITING_SEMANTIC_VALIDATION
Jatoba bark (Hymenaea courbaril) contains phenolic compounds that demonstrate anti-inflammatory activity with an IC50 of 225 ± 2 µg/mL in mouse macrophages and bacteriostatic effects against multidrug-resistant bacteria at 2.5–5 mg/mL MIC. Clinical research in soccer players shows the extract reduces inflammation markers and maintains testosterone levels better than placebo over 8 weeks.
Reported Benefits (Provisional)
Origin & History
Jatoba (Hymenaea courbaril) is a large leguminous tree native to the tropical rainforests of Central and South America, particularly Brazil, Peru, and Colombia. Its resinous bark is traditionally revered for its potent antioxidant, immune-boosting, and energy-enhancing properties, making it a significant functional botanical.
Research Narrative (Provisional)
Scientific studies support Jatoba's antioxidant, antimicrobial, and anti-inflammatory properties, particularly its effects on cardiovascular and neuroprotective activity. Research also indicates its potential for immune modulation, respiratory benefits, and enhancement of the gut microbiome.
Preparation & Dosage
Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.
Nutritional Profile
- Minerals: Calcium, Magnesium, Potassium, Iron, Zinc. - Vitamins: A, C, E, B vitamins (Thiamine, Riboflavin, Niacin). - Phytochemicals & Bioactives: Flavonoids, Terpenes (including rare sesquiterpenes), Lignans, Saponins, Tannins, Alkaloids, Coumarins, Phytoalexins. - Other: Dietary fiber.
Reported Mechanism (Provisional)
Jatoba bark's phenolic compounds exert anti-inflammatory effects by inhibiting inflammatory pathways in macrophages with demonstrated IC50 values of 225 ± 2 µg/mL. The extract modulates stress hormone response by reducing cortisol elevation (58.3% vs 150% in controls) and prevents testosterone decline during physical stress. Antimicrobial activity occurs through bacteriostatic mechanisms against resistant bacterial strains including MRSA and Enterococcus faecalis.
Clinical Narrative (Provisional)
One randomized, placebo-controlled trial in professional soccer players over 8 weeks demonstrated Jatoba sap extract's anti-inflammatory effects, showing reduced CRP variation and LDH levels (-61% difference vs control). The study revealed hormonal benefits with cortisol rising only 58.3% compared to 150% in placebo group, while maintaining testosterone levels versus significant decline in controls. Limited preclinical studies show antiproliferative effects against gastric cancer cells (GI50 = 35 ± 1 µg/mL) and breast cancer cells (GI50 = 89 ± 4 µg/mL). Evidence remains preliminary with only one human clinical trial available.
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