Hermetica Superfood Encyclopedia
Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.
Review flags: AWAITING_SEMANTIC_VALIDATION
Cornelian cherry (Cornus mas) contains loganoic acid and cornuside, which suppress inflammatory cytokines IL-6, IL-8, and TNF-α while providing antioxidant protection. Clinical research demonstrates its ability to reduce nitric oxide production and inhibit NF-κB activation in macrophage models.
Reported Benefits (Provisional)
Origin & History
The Cornelian Cherry (*Cornus mas*) is a deciduous shrub or small tree native to Eastern Europe and Western Asia. It thrives in temperate climates and is recognized for its tart, vibrant red fruits. This botanical is valued for its dense concentration of bioactive compounds that support cardiovascular and metabolic health.
Research Narrative (Provisional)
Numerous studies, including in vitro and animal models, support the Cornelian Cherry's potent antioxidant, anti-inflammatory, and cardioprotective properties. Research highlights its efficacy in metabolic regulation and immune support, substantiating its traditional uses.
Preparation & Dosage
Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.
Nutritional Profile
- Macros: Dietary Fiber (promoting digestive wellness, blood sugar regulation). - Vitamins: Vitamin C (enhancing immune function, collagen synthesis, skin vitality). - Minerals: Potassium, Magnesium, Calcium (supporting cardiovascular, bone, muscle health). - Phytochemicals: Anthocyanins, Polyphenols, Flavonoids (providing antioxidant protection, cardiovascular support, anti-inflammatory, neuroprotective benefits). - Organic Acids: Malic acid, Citric acid (supporting metabolic health, liver detoxification).
Reported Mechanism (Provisional)
Cornelian cherry's primary bioactive compounds loganoic acid and cornuside suppress pro-inflammatory cytokines including interleukin-6, IL-8, and tumor necrosis factor-α in human keratinocytes and fibroblasts. The extract inhibits NF-κB activation, a key inflammatory pathway implicated in chronic diseases. Additionally, it demonstrates enzyme inhibition of α-amylase and α-glucosidase, contributing to metabolic regulation.
Clinical Narrative (Provisional)
Macrophage model studies show cornelian cherry nanoparticles significantly reduce nitric oxide, IL-12, and TNF release with apparent NF-κB suppression. Wistar rat studies demonstrate the extract's ability to suppress IL-1β and IL-13 levels while reducing IL-6 and TNF-α concentrations. Antioxidant research using DPPH, ABTS, and FRAP assays shows cornelian cherry extracts reach 898.7 mg GAE/L of total polyphenols, representing a 30-fold increase over controls. However, human clinical trials are limited, with most evidence derived from in vitro and animal studies.
Also Known As
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