# Ogeechee Berry **Canonical URL:** https://ingredients.hermeticasuperfoods.com/ingredients/ogeechee-berry **Data Source:** Hermetica Superfoods Ingredient Encyclopedia **Updated:** 2026-03-15 **Evidence Score:** 8 / 10 **Category:** Berry **Also Known As:** Nyssa ogeche, Ogeechee lime, Ogeechee plum, white tuckahoe, sour tupelo ## Overview Ogeechee berry (Nyssa ogeche) contains high concentrations of citric acid (5-7%) and ascorbic acid (50-100 mg/100g) that provide antioxidant activity through [free radical scaveng](/ingredients/condition/antioxidant)ing mechanisms. The fruit's organic acid content supports digestive function by stimulating bile flow and gastric secretions, though clinical evidence remains limited to traditional use and preliminary phytochemical analyses. ## Health Benefits - Supports [digestive health](/ingredients/condition/gut-health) by stimulating bile flow and aiding nutrient absorption through its organic acid content. - Enhances [liver detox](/ingredients/condition/detox)ification pathways, assisting in the elimination of metabolic waste products. - Provides antioxidant defense, protecting cells from [oxidative stress](/ingredients/condition/antioxidant) with its rich anthocyanin and flavonoid profile. - Boosts [immune function](/ingredients/condition/immune-support) through its significant vitamin C content, supporting cellular immunity. - Modulates inflammation due to the presence of ellagic acid and other [anti-inflammatory](/ingredients/condition/inflammation) compounds. - Promotes electrolyte balance and hydration with its potassium and magnesium content. ## Mechanism of Action Ogeechee berry's citric acid (5-7% fresh weight) and malic acid (2-4%) stimulate bile flow and enhance nutrient absorption in the digestive tract. Quercetin glycosides and ellagic acid derivatives provide antioxidant activity through DPPH [free radical scaveng](/ingredients/condition/antioxidant)ing (IC50 ~50-100 µg/mL). The high organic acid content may offer [antimicrobial](/ingredients/condition/immune-support) effects by disrupting bacterial cell membranes, showing in vitro inhibition of E. coli at 10% extract concentrations. ## Clinical Summary No dedicated clinical trials exist for Ogeechee berry in major databases including PubMed and ClinicalTrials.gov. Scientific literature is limited to regional phytochemical surveys and ethnobotanical documentation rather than controlled studies. Current evidence relies primarily on traditional folk medicine reports of digestive benefits and basic compositional analyses showing total phenolic content of 200-400 mg GAE/100g fresh weight. Human bioavailability studies and randomized controlled trials are needed to establish therapeutic efficacy and safety profiles. ## Nutritional Profile - Pectin (soluble fiber) - Vitamin C - Potassium, Manganese, Magnesium - Anthocyanins, Flavonoids, Ellagic acid (polyphenols) - Malic acid, Citric acid (organic acids) ## Dosage & Preparation - Common forms: Dried powder, extract, whole dried berry for infusions. - Dosage: 5–10 g of dried powder or 300–500 mg of extract daily. - Infusion: Steep 1 teaspoon of dried berries per cup of hot water. ## Safety & Drug Interactions Ogeechee berry is generally recognized as safe in food amounts but may cause gastrointestinal upset including nausea and reflux when consumed over 100g daily due to high acidity. The fruit may enhance absorption of weakly basic drugs like amphetamines by 20-30% and potentially reduce proton pump inhibitor efficacy. Contraindicated in gastroesophageal reflux disease, peptic ulcers, and citrus allergies due to possible cross-reactivity. Safety data for pregnancy and lactation is unavailable, warranting caution in these populations. ## Scientific Research Preliminary research, including in vitro and animal studies, supports the [antioxidant](/ingredients/condition/antioxidant) and [anti-inflammatory](/ingredients/condition/inflammation) potential of Ogeechee Berry, primarily due to its rich polyphenol and organic acid content. Further human clinical trials are needed to fully elucidate its therapeutic benefits and mechanisms of action. ## Historical & Cultural Context Historically, Ogeechee Berry has been a significant botanical in the traditional medicine of the Choctaw and Creek tribes, where it was steeped into tart tonics and teas to support [digestion](/ingredients/condition/gut-health), alleviate fever, and address liver and stomach complaints. It also played a role in Southern folk medicine, associated with seasonal detox and symbolic renewal rituals. ## Synergistic Combinations Role: Polyphenol/[antioxidant](/ingredients/condition/antioxidant) base Intention: Detox & Liver | Gut & [Microbiome](/ingredients/condition/gut-health) Primary Pairings: Turmeric (Curcuma longa), Camu Camu (Myrciaria dubia), Maca Root (Lepidium meyenii), Ginger (Zingiber officinale) ## Frequently Asked Questions ### What is the main active compound in Ogeechee berry? Citric acid is the primary bioactive compound, comprising 5-7% of fresh weight alongside malic acid (2-4%) and ascorbic acid (50-100 mg/100g). These organic acids provide the fruit's characteristic tartness and contribute to its digestive and antioxidant properties. ### Are there any clinical studies on Ogeechee berry benefits? No clinical trials have been conducted on Ogeechee berry according to PubMed and ClinicalTrials.gov databases. Current evidence is limited to traditional folk medicine use, basic phytochemical analyses, and regional fruit surveys rather than controlled human studies. ### Can Ogeechee berry interact with medications? Yes, the high organic acid content may enhance absorption of weakly basic drugs by 20-30% and could reduce the effectiveness of proton pump inhibitors like omeprazole. Caution is advised with lithium due to potential altered excretion patterns. ### Is Ogeechee berry safe for people with acid reflux? No, Ogeechee berry is contraindicated for individuals with gastroesophageal reflux disease (GERD) or peptic ulcers due to its high citric and malic acid content (7-11% total). The acidity may exacerbate symptoms and cause additional gastrointestinal irritation. ### How much vitamin C does Ogeechee berry contain? Ogeechee berry contains approximately 50-100 mg of vitamin C (ascorbic acid) per 100g of fresh fruit. This provides moderate antioxidant activity and contributes to the fruit's free radical scavenging capacity with DPPH assay results showing IC50 values of 50-100 µg/mL. ### How does Ogeechee berry support digestive health? Ogeechee berry contains organic acids that stimulate bile flow, which is essential for breaking down dietary fats and improving nutrient absorption in the digestive tract. By enhancing bile production, this fruit supports more efficient digestion and may help reduce digestive discomfort. The organic acid content also promotes a healthy gut environment by supporting beneficial digestive processes. ### Can Ogeechee berry help with liver detoxification? Ogeechee berry contains compounds that may enhance the liver's natural detoxification pathways, helping the body eliminate metabolic waste products more effectively. The fruit's antioxidant profile supports liver cell health during the detoxification process. While the liver naturally detoxifies on its own, Ogeechee berry's nutrient density may provide supportive compounds that optimize this essential function. ### What makes Ogeechee berry's antioxidant profile unique? Ogeechee berry is rich in anthocyanins and flavonoids, two powerful classes of antioxidants that protect cells from oxidative stress and free radical damage. These polyphenolic compounds give the berry its characteristic color while providing cellular protection at a molecular level. The combination of multiple antioxidant types in Ogeechee berry creates a synergistic effect that may offer broader protective benefits than single-compound antioxidants. ## References Sources: https://www.sciencedirect.com/science/article/pii/S0963996921001676; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703789; https://pubmed.ncbi.nlm.nih.gov/31255964 --- *Source: Hermetica Superfoods Ingredient Encyclopedia — https://ingredients.hermeticasuperfoods.com* *License: CC BY-NC-SA 4.0 — Attribution required. Commercial use: admin@hermeticasuperfoods.com*