MODERATE — Monitor Closely
CAUTION — monitor digoxin levels; spironolactone may also interfere with digoxin lab assays
Evidence level: STRONG
Spironolactone can raise digoxin levels and interfere with digoxin blood tests, making monitoring unreliable.
Spironolactone reduces renal tubular secretion of digoxin and may interfere with digoxin assays. Can increase digoxin levels by 25%.
Monitor digoxin levels when starting spironolactone. Be aware that some digoxin assays may give falsely elevated readings.
Take Spironolactone and Digoxin as prescribed by your healthcare provider. If both are taken daily, maintain consistent timing for each. When picking up a new prescription, always ask your pharmacist to review your full medication list for timing conflicts.
Renal impairment, elderly, concomitant diuretics
Nausea, vomiting, visual disturbances, bradycardia, confusion
Request digoxin level monitoring. Discuss which digoxin assay is used.
Discuss safer alternatives with your healthcare provider. They can recommend substitutions based on your specific health goals while minimizing interaction risks. Always bring a complete list of everything you take to your appointments.
Spironolactone can raise digoxin levels and interfere with digoxin blood tests, making monitoring unreliable.
Take Spironolactone and Digoxin as prescribed by your healthcare provider. If both are taken daily, maintain consistent timing for each. When picking up a new prescription, always ask your pharmacist to review your full medication list for timing conflicts.
Nausea, vomiting, visual disturbances, bradycardia, confusion
Discuss safer alternatives with your healthcare provider. They can recommend substitutions based on your specific health goals while minimizing interaction risks. Always bring a complete list of everything you take to your appointments.
Request digoxin level monitoring. Discuss which digoxin assay is used.
Or browse the full interaction database (121,000+ pairs).