MAJOR — Use With Caution
FDA-documented interaction. Reduce digoxin dose by approximately 50% when starting amiodarone. Monitor digoxin levels closely.
Evidence level: STRONG
Amiodarone can nearly double the amount of digoxin in your blood by slowing how your body eliminates it. Since digoxin has a very narrow safety margin, this can quickly lead to digoxin toxicity.
Amiodarone inhibits P-glycoprotein (P-gp) and renal tubular secretion of digoxin, increasing digoxin serum levels by 70-100%. FDA labels for both drugs document this interaction.
Your digoxin dose should be cut roughly in half when amiodarone is started. Get regular blood tests to check your digoxin level. Report any nausea, vision changes, or heart rhythm irregularities.
Take Digoxin and Amiodarone as prescribed by your healthcare provider. If both are taken daily, maintain consistent timing for each. Ask your pharmacist about optimal spacing — they have access to comprehensive interaction databases and can provide personalized timing guidance.
Renal impairment, elderly, hypokalemia, hypothyroidism
Nausea, vomiting, loss of appetite, visual disturbances (yellow-green halos, blurred vision), slow or irregular heartbeat, confusion, weakness
Request digoxin dose reduction (typically 50%) when starting amiodarone. Schedule digoxin level monitoring. Discuss target digoxin therapeutic range (0.5-2.0 ng/mL, ideally 0.5-0.9).
Discuss safer alternatives with your healthcare provider. They can recommend substitutions based on your specific health goals while minimizing interaction risks. Always bring a complete list of everything you take to your appointments.
Amiodarone can nearly double the amount of digoxin in your blood by slowing how your body eliminates it. Since digoxin has a very narrow safety margin, this can quickly lead to digoxin toxicity.
Take Digoxin and Amiodarone as prescribed by your healthcare provider. If both are taken daily, maintain consistent timing for each. Ask your pharmacist about optimal spacing — they have access to comprehensive interaction databases and can provide personalized timing guidance.
Nausea, vomiting, loss of appetite, visual disturbances (yellow-green halos, blurred vision), slow or irregular heartbeat, confusion, weakness
Discuss safer alternatives with your healthcare provider. They can recommend substitutions based on your specific health goals while minimizing interaction risks. Always bring a complete list of everything you take to your appointments.
Request digoxin dose reduction (typically 50%) when starting amiodarone. Schedule digoxin level monitoring. Discuss target digoxin therapeutic range (0.5-2.0 ng/mL, ideally 0.5-0.9).
Or browse the full interaction database (121,000+ pairs).