MAJOR — Use With Caution
FDA-documented interaction. Electrolyte monitoring essential. Potassium supplementation usually needed. Maintain potassium >4.0 mEq/L in digoxin patients.
Evidence level: STRONG
Furosemide (Lasix) depletes potassium and magnesium from your body. Low potassium makes your heart much more sensitive to digoxin, so even normal digoxin levels can become toxic and cause dangerous heart rhythms.
Furosemide causes potassium and magnesium wasting. Hypokalemia and hypomagnesemia increase sensitivity to digoxin toxicity even at therapeutic digoxin levels. FDA digoxin label warns about electrolyte disturbances from diuretics.
If you take both medications, regular blood tests for potassium and magnesium are essential. Take potassium supplements as prescribed. Eat potassium-rich foods (bananas, oranges, potatoes).
Take Furosemide and Digoxin as prescribed by your healthcare provider. If both are taken daily, maintain consistent timing for each. When picking up a new prescription, always ask your pharmacist to review your full medication list for timing conflicts.
Inadequate potassium supplementation, poor dietary potassium intake, renal impairment, concurrent corticosteroids
Nausea, vomiting, loss of appetite, visual disturbances, irregular heartbeat, fatigue, confusion, muscle cramps
Monitor potassium and magnesium regularly. Supplement potassium to maintain >4.0 mEq/L. Consider potassium-sparing diuretic addition. Monitor digoxin levels.
Discuss safer alternatives with your healthcare provider. They can recommend substitutions based on your specific health goals while minimizing interaction risks. Always bring a complete list of everything you take to your appointments.
Furosemide (Lasix) depletes potassium and magnesium from your body. Low potassium makes your heart much more sensitive to digoxin, so even normal digoxin levels can become toxic and cause dangerous heart rhythms.
Take Furosemide and Digoxin as prescribed by your healthcare provider. If both are taken daily, maintain consistent timing for each. When picking up a new prescription, always ask your pharmacist to review your full medication list for timing conflicts.
Nausea, vomiting, loss of appetite, visual disturbances, irregular heartbeat, fatigue, confusion, muscle cramps
Discuss safer alternatives with your healthcare provider. They can recommend substitutions based on your specific health goals while minimizing interaction risks. Always bring a complete list of everything you take to your appointments.
Monitor potassium and magnesium regularly. Supplement potassium to maintain >4.0 mEq/L. Consider potassium-sparing diuretic addition. Monitor digoxin levels.
Or browse the full interaction database (121,000+ pairs).