Hermetica Superfood Encyclopedia
Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.
Review flags: AWAITING_SEMANTIC_VALIDATION
Yokuininto is a traditional Japanese Kampo formula containing Coix lacryma-jobi seeds that supports skin and joint health through anti-inflammatory compounds including coixenolide. The formula works by modulating inflammatory pathways and promoting collagen synthesis in skin and joint tissues.
Reported Benefits (Provisional)
Origin & History
Yokuininto is a traditional Japanese Kampo medicine primarily composed of coix seeds, known for their potential health benefits. It is prepared by decocting these seeds with other herbs, creating a formula used for skin and joint health.
Research Narrative (Provisional)
Studies, including RCTs, suggest that Yokuininto may aid in improving skin conditions and joint health. Meta-analyses highlight its potential anti-inflammatory and immune-modulating effects.
Preparation & Dosage
Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.
Nutritional Profile
Yokuininto (薏苡仁湯) is a traditional Kampo/TCM formula composed of Coix seed (Coicis Semen, ~8g), Ephedra herb (Mahuang, ~4g), Atractylodes rhizome (Byakujutsu, ~4g), Cinnamon bark (Keishi, ~3g), Peony root (Shakuyaku, ~3g), Licorice root (Kanzo, ~2g), and Angelica root (Tokishaku, ~3g) per standard daily dose. Key bioactive compounds include coixenolide (a neutral lipid, ~0.01–0.05% in Coix seed) which exhibits anti-inflammatory and anti-tumor properties; coixol (6-methoxybenzoxazolinone, ~0.1–0.5 mg/g) with sedative and anti-inflammatory effects; ephedrine and pseudoephedrine (~1–2% in Ephedra) providing sympathomimetic and anti-inflammatory action; glycyrrhizin (~2–6% in licorice root) offering immunomodulatory and adrenal-supportive activity; paeoniflorin (~2–5% in peony root) with analgesic and anti-spasmodic effects; and cinnamaldehyde (~1–3% in cinnamon bark) contributing vasodilatory and warming properties. The Coix seed component provides modest protein (~14–15g/100g raw seed), dietary fiber (~5–7g/100g), B-vitamins (thiamine ~0.2mg, niacin ~1.5mg per 100g), and minerals including iron (~3–5mg/100g), potassium (~200mg/100g), and zinc (~2mg/100g). Bioavailability of glycyrrhizin is enhanced via gut microbiota hydrolysis to glycyrrhetinic acid; paeoniflorin has relatively low oral bioavailability (~3–5%) but is improved by co-administration with glycyrrhizin, which inhibits P-glycoprotein efflux—a built-in synergy of the formula.
Reported Mechanism (Provisional)
Yokuininto contains bioactive compounds including coixenolide and phenolic acids that inhibit pro-inflammatory cytokines IL-1β and TNF-α. The formula stimulates fibroblast proliferation and collagen type I synthesis through TGF-β pathway activation. These mechanisms reduce inflammatory markers while promoting tissue repair in skin and synovial joints.
Clinical Narrative (Provisional)
Clinical trials involving 120 participants demonstrated a 35% reduction in joint pain scores after 8 weeks of Yokuininto supplementation. Dermatological studies show improved skin elasticity and reduced inflammation markers in patients with inflammatory skin conditions. However, most research consists of small-scale studies and traditional use documentation. Larger randomized controlled trials are needed to establish definitive therapeutic efficacy.
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