Yi Yi Ren (Coix lacryma-jobi) — Hermetica Encyclopedia
Traditional Chinese Medicine

Yi Yi Ren (Coix lacryma-jobi)

Provisional Moderate Scorebotanical

Hermetica Superfood Encyclopedia

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Yi Yi Ren (Coix lacryma-jobi) contains coixenolide and polysaccharides that exhibit anti-inflammatory and diuretic properties through inhibition of NF-κB signaling pathways. This traditional Chinese medicine seed primarily works by reducing inflammatory cytokines and promoting fluid metabolism.

Screened PMID Records
1
Reported Benefits
Pending
Synergy Review
At a Glance
CategoryTraditional Chinese Medicine
GroupTraditional Chinese Medicine
Public Score StatusProvisional Moderate
Primary KeywordYi Yi Ren benefits
Yi Yi Ren close-up macro showing natural texture and detail — rich in diuretic, anti-inflammatory, antioxidant
Yi Yi Ren (Coix lacryma-jobi) — botanical close-up

Reported Benefits (Provisional)

Yi Yi Ren supports digestive health by promoting bowel regularity and reducing inflammation in the gut. - It enhances skin health by improving moisture retention, leading to a more hydrated and youthful appearance. - This seed aids in weight management by boosting metabolism and promoting fat loss. - Yi Yi Ren has anti-inflammatory properties that can alleviate symptoms of arthritis by reducing joint inflammation. - It supports immune function by enhancing the activity of immune cells, improving the body's ability to fight infections. - The seed promotes kidney health by supporting the elimination of excess fluids, reducing the risk of edema. - It can improve energy levels by enhancing mitochondrial efficiency, leading to increased stamina and vitality.

Origin & History

Yi Yi Ren growing in Southeast Asia — natural habitat
Natural habitat

Yi Yi Ren, also known as Coix lacryma-jobi or Job's tears, is a grain-bearing plant native to Southeast Asia. The seeds are harvested and used in traditional medicine and culinary applications.

Yi Yi Ren has been used in traditional Chinese medicine for its dampness-draining properties. It is also a popular ingredient in Asian cuisine, often used in soups and teas.Traditional Medicine

Research Narrative (Provisional)

Studies on Yi Yi Ren have shown potential benefits in reducing inflammation and supporting digestive health. However, more clinical research is needed to confirm these effects.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

Yi Yi Ren (Coix lacryma-jobi), commonly known as Job's tears or coix seed, has the following nutritional composition per 100g dry weight: Macronutrients: Carbohydrates 52-79g (primarily starch, with resistant starch fractions ~5-10% that contribute to prebiotic effects and slower digestion), Protein 13-18g (rich in glutelin and prolamin fractions, containing essential amino acids including leucine ~1.2g, lysine ~0.5g, though lysine-limited compared to ideal protein), Fats 4-7g (including linoleic acid ~55-60% of fatty acid profile, oleic acid ~25-30%, palmitic acid ~12-15%), Dietary Fiber 0.8-2.2g (with both soluble and insoluble fractions). Micronutrients: Calcium 20-40mg, Phosphorus 200-300mg, Magnesium 50-80mg, Potassium 200-280mg, Iron 1.5-3.5mg, Zinc 1.5-2.5mg, B vitamins including Thiamine (B1) 0.2-0.4mg, Riboflavin (B2) 0.1-0.2mg, Niacin (B3) 1.5-2.5mg, Vitamin E (tocopherols) 0.5-1.2mg. Bioactive Compounds: Coixenolide (lipid fraction) ~0.1-0.5% with demonstrated anti-tumor and anti-inflammatory properties; Coixol (6-methoxybenzoxazolinone) ~0.1-0.3% with analgesic and muscle-relaxant activity; Polysaccharides (coixan A, B, C) ~5-8% with immunomodulatory and hypoglycemic effects; Phytosterols including beta-sitosterol and stigmasterol ~50-100mg; Polyphenols and flavonoids ~0.3-0.8% with antioxidant activity (DPPH IC50 approximately 2-5 mg/mL). Bioavailability Notes: Starch digestibility is moderate; soaking and cooking significantly improve nutrient bioavailability by reducing phytic acid content (~0.8-1.2g/100g raw), which otherwise binds minerals like iron, zinc, and calcium and reduces their absorption by 20-50%. The coixenolide fraction shows better bioavailability when consumed with dietary fats. Resistant starch content supports colonic fermentation, producing short-chain fatty acids beneficial for gut health. Processing methods such as roasting can reduce some heat-sensitive B vitamins by 10-20% but may enhance certain bioactive compound concentrations.

Reported Mechanism (Provisional)

Mechanism of Action

Yi Yi Ren's bioactive compounds, particularly coixenolide and β-sitosterol, inhibit nuclear factor-kappa B (NF-κB) signaling, reducing pro-inflammatory cytokines like TNF-α and IL-6. The polysaccharide fraction enhances aquaporin expression in skin cells, improving moisture retention. Additionally, coixenolide activates AMP-activated protein kinase (AMPK), promoting lipid oxidation and metabolic enhancement.

Clinical Narrative (Provisional)

Limited human studies have examined Yi Yi Ren's effects, with most research conducted in animal models and in vitro studies. A small clinical trial (n=60) showed modest improvements in digestive symptoms over 8 weeks. Dermatological studies in mice demonstrated 15-20% improvement in skin hydration markers. Weight management claims are primarily supported by rodent studies showing 8-12% reduction in body weight, though human efficacy data remains insufficient.

Also Known As

Coix lacryma-jobiJob's tearsAdlayChinese pearl barleyCoix seedMa-yuenTear grassAdlay millet

Explore the Full Encyclopedia

Browse evidence-gated ingredient records with transparent editorial and citation standards.

Browse Ingredients
These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.
From the Hermetica Research Desk

Research updates — and 25% off your first order

Join our list for source-aware wellness education, review-state updates, and product news — and unlock 25% off your first Hermetica order. Educational content is not medical advice. No spam, unsubscribe anytime.

Educational content only — not medical advice.