
Hermetica Superfood Encyclopedia
Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.
Review flags: AWAITING_SEMANTIC_VALIDATION
Vitamin D3 from lichen provides cholecalciferol derived from plant sources, making it the only vegan form of vitamin D3 available. It functions by converting to calcitriol in the kidneys, which regulates calcium absorption and immune cell modulation.

Reported Benefits (Provisional)
Origin & History

Vitamin D3 from Lichen is a plant-based form of vitamin D3, making it suitable for vegans. It is derived from lichen, a symbiotic organism composed of fungi and algae.
Research Narrative (Provisional)
Studies indicate that lichen-derived Vitamin D3 is effective in raising serum vitamin D levels. It is considered equivalent to animal-derived D3 in terms of bioavailability.
Preparation & Dosage
Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.
Nutritional Profile
Vitamin D3 (cholecalciferol) derived from lichen (Cladonia or Usnea species) is a vegan-sourced form of Vitamin D3, biochemically identical to animal-derived D3. Key bioactive compound: cholecalciferol at typical supplement concentrations of 400–5000 IU (10–125 mcg) per serving. Lichen-derived D3 contains no significant macronutrients (protein, fat, carbohydrates) in isolated supplement form. Micronutrient content is primarily the D3 molecule itself, with trace amounts of naturally occurring plant sterols and lipids from the lichen extraction matrix. Bioavailability: Lichen-derived D3 demonstrates comparable bioavailability to lanolin-derived D3 (from sheep's wool), with absorption rates of approximately 60–80% when taken with a fat-containing meal, as cholecalciferol is a fat-soluble vitamin. Once absorbed, D3 is hydroxylated in the liver to 25-hydroxyvitamin D [25(OH)D], the primary circulating form, and further converted in the kidneys to the active hormone 1,25-dihydroxyvitamin D (calcitriol). Studies confirm lichen-sourced D3 effectively raises serum 25(OH)D levels similarly to conventional D3, making it a clinically validated vegan alternative. No significant difference in absorption compared to animal-sourced D3 has been noted in bioequivalence studies.
Reported Mechanism (Provisional)
Lichen-derived cholecalciferol undergoes 25-hydroxylation in the liver to form 25(OH)D3, then 1α-hydroxylation in kidneys to produce active calcitriol (1,25(OH)2D3). Calcitriol binds to vitamin D receptors (VDR) in intestinal cells, upregulating calcium-binding proteins like calbindin-D9k for enhanced calcium absorption. It also modulates immune cells by regulating antimicrobial peptide production and T-cell differentiation.
Clinical Narrative (Provisional)
Randomized controlled trials show lichen-derived D3 raises 25(OH)D levels comparably to lanolin-based D3, with 1000-4000 IU daily achieving optimal blood levels (30-50 ng/mL) in 8-12 weeks. A 12-week study of 95 vegans found 2000 IU lichen D3 increased serum levels from 16 to 32 ng/mL. Meta-analyses demonstrate D3 supplementation reduces fracture risk by 20% and respiratory infections by 12%. Evidence quality is moderate to high for bone health outcomes, with emerging data on immune and mood benefits.
Also Known As
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