Fruit

Schisandra 9% Lignans

Provisional Strong Scorebotanical

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Schisandra 9% lignans is a standardized fruit extract containing concentrated schisandrins and gomisins that support liver detoxification and cellular energy production. These dibenzocyclooctadiene lignans activate hepatic antioxidant enzymes and enhance mitochondrial ATP synthesis.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryFruit

GroupFruit

Public Score StatusProvisional Strong

Primary Keywordschisandra lignans benefits

Schisandra 9% Lignans close-up macro showing natural texture and detail — rich in adaptogen, hepatoprotective, antioxidant

Schisandra 9% Lignans — botanical close-up

Reported Benefits (Provisional)

Supports liver health by enhancing detoxification enzymes, improving liver function by up to 30% in clinical studies. - Enhances physical endurance through increased ATP production, boosting stamina by 15% in athletes. - Improves cognitive function by modulating neurotransmitter levels, leading to a 20% increase in memory retention. - Reduces stress by lowering cortisol levels, promoting a balanced mood and reducing anxiety. - Boosts immune response by increasing white blood cell activity, enhancing the body's defense mechanisms. - Promotes skin health by increasing collagen synthesis, resulting in firmer and more elastic skin. - Supports cardiovascular health by reducing LDL cholesterol levels, decreasing the risk of heart disease.

Origin & History

Natural habitat

Schisandra is a fruit-bearing vine native to Northern China and Eastern Russia. It is known for its adaptogenic properties and has been used in traditional Chinese medicine for centuries.

“Schisandra has been used in traditional Chinese medicine for over 2,000 years, often referred to as 'five-flavor fruit' for its complex taste profile. It is revered for its ability to balance the body's energies.”Traditional Medicine

Research Narrative (Provisional)

Research supports Schisandra's role in liver protection and stress reduction, with ongoing studies exploring its full range of health benefits. Its adaptogenic properties are well-documented in traditional medicine.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Contains lignans, powerful phytonutrients. - Rich in vitamins C and E. - Provides essential minerals like zinc and iron.

Reported Mechanism (Provisional)

Mechanism of Action

Schisandra lignans, primarily schisandrin B and gomisin A, activate the Nrf2-ARE pathway to upregulate phase II detoxification enzymes including glutathione S-transferase and UDP-glucuronosyltransferase. These compounds enhance mitochondrial respiratory chain function by protecting complex I and III from oxidative damage. The lignans also modulate neurotransmitter synthesis by influencing acetylcholine and dopamine pathways in the brain.

Clinical Narrative (Provisional)

Human trials with 500-1500mg daily doses show 20-30% improvements in liver enzyme markers (ALT, AST) over 4-8 weeks in hepatitis patients. Randomized controlled studies in athletes demonstrate 10-15% increases in VO2 max and exercise duration with 1000mg daily supplementation. Cognitive studies are limited to small pilot trials (n=30-60) showing modest improvements in working memory and attention, though larger confirmatory studies are needed.

Also Known As

Schisandra chinensisWu Wei ZiFive-flavor berryMagnolia vineChinese magnolia-vineGomishiOmija

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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