Mushroom · Mushroom/Fungi

Pleuran

Provisional Moderate Scorebotanical

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Pleuran is a beta-1,3/1,6-glucan polysaccharide extracted from oyster mushrooms (Pleurotus ostreatus) that modulates immune function. It activates macrophages and natural killer cells through Dectin-1 receptors, enhancing pathogen recognition and inflammatory response.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryMushroom

GroupMushroom/Fungi

Public Score StatusProvisional Moderate

Primary KeywordPleuran benefits

Pleuran close-up macro showing natural texture and detail — rich in immunomodulatory, antioxidant, anti-inflammatory

Pleuran — botanical close-up

Reported Benefits (Provisional)

Enhances immune function by stimulating macrophages and natural killer cells, boosting the body's defense against infections. This leads to a more robust immune response. - Reduces inflammation by modulating cytokine production, which alleviates symptoms of chronic inflammatory conditions. This supports joint and tissue health. - Provides antioxidant protection by neutralizing free radicals, which prevents cellular damage and aging. This enhances overall health and longevity. - Supports respiratory health by reducing the severity and duration of respiratory infections. This promotes easier breathing and lung function. - Improves gut health by promoting beneficial gut bacteria growth and enhancing gut barrier function. This supports digestion and nutrient absorption. - Enhances skin health by reducing oxidative stress and inflammation, leading to improved skin appearance and elasticity. This promotes a youthful complexion. - Supports cardiovascular health by improving blood lipid profiles and reducing oxidative stress. This lowers the risk of heart disease and supports vascular health.

Origin & History

Natural habitat

Pleuran is a beta-glucan extracted from the mushroom Pleurotus ostreatus, commonly known as the oyster mushroom. This compound is highly valued for its immunomodulatory properties.

“Pleuran has been used in traditional medicine, particularly in Eastern Europe, for its health-promoting properties. It has gained popularity in Western countries as a dietary supplement.”Traditional Medicine

Research Narrative (Provisional)

Several studies have shown Pleuran's efficacy in boosting immune responses and its potential role in reducing cholesterol. However, more clinical trials are needed to fully understand its effects on human health.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Rich in polysaccharides, primarily beta-glucans. - Contains essential amino acids. - Low in calories and fats. - Provides dietary fiber.

Reported Mechanism (Provisional)

Mechanism of Action

Pleuran binds to Dectin-1 receptors on immune cells, triggering complement receptor 3 (CR3) activation and downstream signaling cascades. This activation stimulates macrophage phagocytosis and enhances natural killer cell cytotoxicity. The beta-1,3/1,6-glucan structure also modulates NF-κB and MAPK pathways, regulating cytokine production including TNF-α and interleukin-1β.

Clinical Narrative (Provisional)

Human studies with Pleuran have primarily focused on respiratory infections and immune markers, with doses ranging from 100-400mg daily. A randomized controlled trial of 200 participants showed 30% reduction in upper respiratory tract infection frequency over 12 weeks. Several smaller studies (20-60 participants) demonstrated increased natural killer cell activity and improved cytokine profiles. However, most research consists of short-term studies with limited sample sizes, requiring larger long-term trials for definitive efficacy claims.

Also Known As

Pleurotus ostreatus beta-glucanOyster mushroom extractβ-1,3/1,6-glucanImmunoglukanPleurotus extractHiratake beta-glucanShiméjì extract

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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