Seed & Nut · Seed

Perilla Seeds

Provisional Moderate Scorebotanical

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Perilla seeds contain high concentrations of alpha-linolenic acid (ALA), an omega-3 fatty acid that reduces inflammatory markers and supports cardiovascular function. The rosmarinic acid in perilla seeds acts as a potent antioxidant, protecting cellular membranes from lipid peroxidation.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategorySeed & Nut

GroupSeed

Public Score StatusProvisional Moderate

Primary Keywordperilla seeds benefits

Perilla Seeds close-up macro showing natural texture and detail — rich in antioxidant, anti-inflammatory, antiallergic

Perilla Seeds — botanical close-up

Reported Benefits (Provisional)

Perilla Seeds are high in omega-3 fatty acids, which reduce inflammation and support cardiovascular health. - They contain antioxidants like rosmarinic acid, protecting cells from oxidative stress and promoting longevity. - Rich in fiber, they support digestive health by promoting regular bowel movements. - The seeds improve skin health by enhancing hydration and elasticity, thanks to their fatty acid content. - They aid in weight management by increasing feelings of fullness, helping control appetite. - High in phytosterols, they help lower cholesterol levels, reducing heart disease risk. - Contain flavonoids, which have anti-inflammatory properties, supporting overall health.

Origin & History

Natural habitat

Perilla seeds come from the Perilla frutescens plant, native to East Asia. They are commonly used in Korean and Japanese cuisines for their nutty flavor and nutritional benefits.

“Perilla seeds have been used in traditional East Asian cuisines and medicine for centuries, valued for their flavor and health benefits.”Traditional Medicine

Research Narrative (Provisional)

Studies highlight Perilla seeds' high omega-3 content, which supports cardiovascular and cognitive health. Further research is needed to confirm additional benefits.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Rich in omega-3 and omega-6 fatty acids. - Contains antioxidants and polyphenols. - High in protein and fiber. - Low in carbohydrates.

Reported Mechanism (Provisional)

Mechanism of Action

Alpha-linolenic acid from perilla seeds converts to EPA and DHA, inhibiting cyclooxygenase and lipoxygenase enzymes that produce inflammatory prostaglandins and leukotrienes. Rosmarinic acid scavenges free radicals and upregulates antioxidant enzymes like superoxide dismutase and catalase. The fiber content promotes beneficial gut bacteria growth and short-chain fatty acid production.

Clinical Narrative (Provisional)

Small human studies with 20-40 participants show perilla seed oil (6-10g daily) reduces inflammatory markers like IL-6 and TNF-alpha by 15-25% over 8-12 weeks. Animal studies demonstrate improved lipid profiles and reduced oxidative stress markers. However, large-scale randomized controlled trials are lacking, and most evidence comes from preliminary research with limited sample sizes.

Also Known As

Perilla frutescensKorean perillaWild sesameBeefsteak plant seedsShiso seedsEgomaZi su ziDeulkkae

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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