Hermetica Superfood Encyclopedia
Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.
Review flags: AWAITING_SEMANTIC_VALIDATION
Mango seed (Mangifera indica) contains high concentrations of gallic acid (586.68 mg/g) and other phenolic compounds that demonstrate potent antioxidant activity, achieving 95.86% DPPH radical scavenging through electron donation mechanisms. The kernel extract shows antimicrobial properties and dose-dependent cytotoxicity against HepG2 liver cancer cells with an IC₅₀ of 140 μg/mL.
Reported Benefits (Provisional)
Origin & History
Mango Seed (Mangifera indica), the kernel of the mango fruit, originates from South Asia, particularly India and Myanmar. It is now cultivated worldwide in tropical regions. This often-discarded part of the fruit is gaining recognition in functional nutrition for its unique profile of fats, fiber, and bioactive compounds.
Research Narrative (Provisional)
Studies indicate mango seed's potential in cardiovascular health, particularly in lowering LDL cholesterol. Research also highlights its antioxidant and antimicrobial properties, with emerging evidence for its role in metabolic health and anti-obesity effects.
Preparation & Dosage
Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.
Nutritional Profile
- Phytochemicals: Mangiferin, gallotannins, polyphenols, flavonoids (antioxidant protection, immune support). - Fatty Acids: Oleic and stearic acids (heart health, metabolic regulation). - Minerals: Potassium, magnesium, calcium, iron (bone strength, electrolyte balance). - Protein: Essential amino acids (muscle and metabolic support). - Fiber: Dietary fiber (digestive health, blood sugar regulation). - Vitamins: Small amounts of vitamin C.
Reported Mechanism (Provisional)
Phenolic compounds including gallic acid, caffeic acid, and rutin scavenge free radicals through proton donation and electron transfer while maintaining molecular stability. Antimicrobial action occurs via inhibition of extracellular microbial enzymes, substrate deprivation, and direct interference with oxidative phosphorylation pathways. The compounds also modulate inflammatory pathways by reducing myeloperoxidase activity and inhibiting TNF-α and nitric oxide production in macrophages.
Clinical Narrative (Provisional)
Current evidence is primarily limited to in vitro and animal studies, with no comprehensive human clinical trials identified. Laboratory studies demonstrate 7.4-fold increases in total phenolic content and 2.9-fold increases in DPPH antioxidant capacity compared to controls. Animal models show anti-inflammatory effects through reduced MPO activity and cytokine inhibition. The cytotoxic effects against HepG2 cells suggest potential therapeutic applications, but human efficacy and safety data remain absent from the current literature.
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