Hermetica Superfood Encyclopedia
Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.
Review flags: AWAITING_SEMANTIC_VALIDATION
Java Plum Seed contains jambosine, ellagic acid, and gallic acid that inhibit protein tyrosine phosphatase 1B (PTP1B) with IC50 values of 0.77 mg/mL while blocking starch-to-sugar conversion. These bioactive compounds demonstrate antioxidant activity with IC50 of 35.4 µg/mL and total phenolic content of 415 mg GAE/g dried extract.
Reported Benefits (Provisional)
Origin & History
Java Plum Seed, derived from the fruit of Syzygium cumini (also known as Jamun), is native to the Indian subcontinent and thrives in tropical and subtropical regions. Revered in traditional medicine systems, the seed is a potent source of bioactive compounds. It is valued in functional nutrition for its significant role in supporting blood sugar regulation, cardiovascular wellness, and digestive health.
Research Narrative (Provisional)
Scientific studies support Java Plum Seed's efficacy in blood sugar regulation, cardiovascular wellness, and antioxidant defense. Research highlights its anti-inflammatory and metabolic benefits, particularly concerning glucose metabolism. Further clinical trials are ongoing to fully elucidate its therapeutic potential.
Preparation & Dosage
Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.
Nutritional Profile
- Jamboline: A unique bioactive compound known for its blood sugar-regulating properties. - Ellagic Acid: A potent polyphenol offering antioxidant and anti-inflammatory benefits. - Flavonoids: Provide antioxidant protection and support cardiovascular health. - Potassium: Essential for blood pressure regulation and electrolyte balance. - Magnesium: Supports metabolic processes, nerve function, and bone health. - Dietary Fiber: Aids digestive health and promotes satiety.
Reported Mechanism (Provisional)
Jambosine inhibits starch-to-sugar conversion while ellagic acid suppresses pro-inflammatory factors including NF-κB and TNF-α pathways. The ethyl acetate fraction containing valoneic acid dilactone inhibits protein tyrosine phosphatase 1B and aldose reductase with IC50 values of 0.165 mg/mL and 0.12 mg/mL respectively. These compounds upregulate Nrf2 pathways while reducing lipid peroxidation and boosting antioxidant enzyme activity.
Clinical Narrative (Provisional)
Current evidence relies primarily on in vitro and extract studies rather than robust clinical trials with human participants. Laboratory studies demonstrate phenolic compounds comprising 45.4% tannic acid, 21.9% gallic acid, and 8.65% ellagic acid of total phenolic content. While general clinical studies reference blood glucose regulation effects, specific participant numbers, dosages, and statistical significance values are not documented in current literature. Further controlled human trials are needed to establish definitive therapeutic efficacy and optimal dosing protocols.
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