Hermetica Superfood Encyclopedia
Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.
Review flags: AWAITING_SEMANTIC_VALIDATION
Green mango leaf (Mangifera indica) contains mangiferin, a xanthone polyphenol that inhibits glucose-metabolizing enzymes α-amylase and α-glucosidase for blood sugar control. Mangiferin also suppresses cancer cell proliferation through Wnt/β-catenin pathway inhibition and Akt phosphorylation suppression.
Reported Benefits (Provisional)
Origin & History
Green Mango Leaf, derived from *Mangifera indica*, originates from Southeast Asia, particularly India, Thailand, and Indonesia. This evergreen tree thrives in tropical and subtropical climates, where its leaves have been traditionally utilized. The leaves are recognized in functional nutrition for their unique bioactive compounds that support metabolic, cardiovascular, and immune health.
Research Narrative (Provisional)
Numerous studies, including in vitro and animal models, support the metabolic and cardiovascular benefits of Green Mango Leaf, particularly highlighting the role of mangiferin. Research also indicates its potent antioxidant, anti-inflammatory, and antimicrobial properties, validating its traditional uses.
Preparation & Dosage
Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.
Nutritional Profile
- Minerals: Potassium, Magnesium, Zinc - Phytochemicals: Mangiferin, Quercetin, Flavonoids, Polyphenols, Tannins
Reported Mechanism (Provisional)
Mangiferin inhibits α-amylase (51.4% at 200 µg/ml) and α-glucosidase (IC₅₀ 21.03 µg/ml) to reduce glucose absorption and improve metabolic regulation. For cancer protection, mangiferin suppresses the Wnt/β-catenin pathway and Akt phosphorylation, causing G₂/M phase cell cycle arrest. The compound activates Nrf2-mediated antioxidant pathways while polyphenols like protocatechuic acid and quercetin provide antimicrobial effects through ATP depletion and membrane depolarization.
Clinical Narrative (Provisional)
Research consists primarily of in vitro and animal studies rather than human clinical trials. Laboratory studies show mango leaf extract increases glucose uptake by 143% in liver cells and demonstrates α-glucosidase inhibition with IC₅₀ values of 21.03-22.01 µg/ml at 500 mg/kg doses. Cancer cell studies indicate cytotoxic effects at concentrations ≥200 µg/ml against tested cell lines. Clinical validation in humans remains limited, with researchers acknowledging the need for further human studies to confirm therapeutic potential and safety profiles.
Also Known As
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