Nootropic & Cognitive · Adaptogen

Centella Asiatica (Gotu Kola Extract)

Provisional Strong Scorebotanical

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Gotu kola (Centella asiatica) contains triterpenoid saponins like asiaticoside and madecassoside that enhance cognitive function by increasing cerebral blood flow and BDNF production. These compounds also support wound healing and venous circulation through collagen synthesis stimulation.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryNootropic & Cognitive

GroupAdaptogen

Public Score StatusProvisional Strong

Primary Keywordgotu kola benefits

Centella Asiatica close-up macro showing natural texture and detail — rich in nootropic, neuroprotective, anxiolytic

Centella Asiatica (Gotu Kola Extract) — botanical close-up

Reported Benefits (Provisional)

Enhances cognitive function and memory by increasing cerebral blood flow, which supplies essential nutrients and oxygen to the brain. This leads to improved mental clarity and recall. - Promotes neuroprotection and brain health by stimulating the production of neurotrophic factors like NGF. This supports neuron growth and repair, enhancing overall brain resilience. - Supports mental clarity and focus by modulating neurotransmitter activity, including serotonin and dopamine. This results in sharper concentration and cognitive processing. - Reduces anxiety and stress by regulating cortisol levels and enhancing GABAergic activity. This promotes a calm and balanced mental state. - Improves mood by increasing the synthesis of serotonin, a key neurotransmitter for emotional well-being. This leads to a more positive outlook and reduced symptoms of depression. - Enhances skin health by promoting collagen synthesis and reducing inflammation. This supports skin elasticity and reduces signs of aging. - Boosts immune function by modulating cytokine production, which enhances the body's defense mechanisms. This contributes to overall health and vitality.

Origin & History

Natural habitat

Centella Asiatica, commonly known as Gotu Kola, is a perennial plant native to Asia. The extract is obtained from the leaves through a process of drying and solvent extraction.

“Used in traditional Ayurvedic and Chinese medicine for its rejuvenating properties. Revered as a 'longevity herb' for its wide-ranging health benefits.”Traditional Medicine

Research Narrative (Provisional)

Several RCTs and meta-analyses support its cognitive and neuroprotective benefits, particularly in improving memory and reducing anxiety.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Rich in triterpenoids, which support cognitive health. - Contains flavonoids with antioxidant properties. - Provides essential nutrients for brain and skin health.

Reported Mechanism (Provisional)

Mechanism of Action

Gotu kola's triterpenoid saponins (asiaticoside, asiatic acid, madecassoside) increase cerebral blood flow by enhancing nitric oxide production and vasodilation. These compounds stimulate BDNF and NGF synthesis, promoting neuroplasticity and neuroprotection. The saponins also activate fibroblast proliferation and collagen synthesis pathways, supporting tissue repair and venous integrity.

Clinical Narrative (Provisional)

Multiple randomized controlled trials with 60-120 participants demonstrate gotu kola's cognitive benefits at 500-750mg daily for 2-6 months. Studies show 8-27% improvements in memory tests and attention span compared to placebo. Clinical trials on venous insufficiency using 60-120mg of total triterpenes daily for 4-8 weeks report 50-70% reduction in ankle swelling and leg pain. Evidence quality is moderate, with most studies being small-scale but well-designed.

Also Known As

Centella asiaticaGotu KolaIndian PennywortBrahmiMandukaparniJi Xue CaoAsiatic PennywortTiger Grass

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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