Fruit · Seed

Bush Mango Seed

Provisional Strong ScoreCompound

Hermetica Superfood Encyclopedia

Published March 15, 2026Last updated March 15, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Bush Mango Seed (Irvingia gabonensis) contains potent phenolic compounds including gallic acid, caffeic acid, and pentagalloylglucose that demonstrate exceptional antioxidant activity with 95.86% DPPH radical scavenging capacity. The seed extract operates through multiple mechanisms including cholesterol regulation, appetite suppression via leptin sensitivity, and metabolic enhancement for weight management.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryFruit

GroupSeed

Public Score StatusProvisional Strong

Primary Keywordbush mango seed benefits

Bush Mango Seed — botanical close-up

Reported Benefits (Provisional)

Regulates metabolism, contributing to healthy weight management and energy balance.

Supports cardiovascular health by aiding in cholesterol regulation

Balances blood sugar levels by enhancing glycemic control

Promotes satiety, helping to manage appetite and food intake

Enhances digestion through its rich fiber content

Strengthens the gut microbiome by providing prebiotic compounds

Origin & History

Natural habitat

Bush Mango Seed, derived from the fruit of Irvingia gabonensis, originates from the tropical rainforests of West and Central Africa. This highly valued seed is a cornerstone of functional nutrition, recognized for its significant metabolic, cardiovascular, and digestive health benefits.

“Bush Mango Seed is a foundational superfood in traditional African medicine and nutrition, revered for sustaining energy, fortifying digestion, and enhancing metabolism. Historically used in rituals, healing meals, and seasonal remedies, its functional benefits are now validated for metabolic health and gut support.”Traditional Medicine

Research Narrative (Provisional)

Scientific studies, including clinical trials, demonstrate Bush Mango Seed's efficacy in regulating metabolism, supporting cardiovascular health, and balancing blood sugar. Research also highlights its role in promoting satiety and enhancing gut microbiome health.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Macronutrients: Soluble fiber, resistant starch, monounsaturated fats, plant protein. - Minerals: Magnesium, potassium, calcium. - Phytochemicals: Ellagic acid, flavonoids, beta-sitosterol, plant sterols, prebiotic compounds.

Reported Mechanism (Provisional)

Mechanism of Action

Bush Mango Seed's bioactive compounds, particularly pentagalloylglucose and gallic acid, enhance leptin sensitivity and regulate adiponectin levels to control appetite and metabolic rate. The phenolic compounds demonstrate potent antioxidant mechanisms through radical scavenging pathways, achieving 95.86% DPPH inhibition and strong reducing power (FRAP correlation r=0.9373). Additional mechanisms include glycemic control through enhanced insulin sensitivity and cardiovascular protection via cholesterol metabolism regulation.

Clinical Narrative (Provisional)

Current research on Bush Mango Seed consists primarily of in vitro studies demonstrating significant bioactive potential, with seed extracts showing IC50 values of 140 μg/mL against HepG2 cells and exceptional antioxidant capacity exceeding ascorbic acid in some assays. While preliminary clinical trials suggest efficacy in weight management, cardiovascular health, and glycemic control, the evidence base requires expansion with larger, well-controlled human studies. The 50% ethanol extracts demonstrated the highest total phenolic content and strongest antioxidant activity in laboratory studies. Most safety and efficacy data currently derives from traditional use patterns and limited clinical observations rather than comprehensive clinical trial programs.

Also Known As

Irvingia gabonensisAfrican mango seedDika nutWild mango seedOgbono seed

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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