STOP — Contraindicated
FDA contraindication. 14-day washout after stopping rasagiline. Also allow adequate venlafaxine washout before starting rasagiline.
Evidence level: STRONG
Effexor (venlafaxine) must not be used with rasagiline (Azilect). The combination can cause potentially fatal serotonin syndrome.
Rasagiline (MAO-B inhibitor) plus venlafaxine (SNRI). FDA rasagiline label contraindicates concurrent use. Serotonin syndrome risk.
Do not combine. 14-day washout required between medications. Ensure both prescribing doctors know about all your medications.
Take Venlafaxine at the same time each day — most people prefer morning with breakfast. Rasagiline follows its prescribed schedule. SNRIs can affect blood pressure (both up and down), so monitor BP if combining with cardiovascular medications.
Higher risk for: elderly, those on multiple serotonergic drugs, people with liver impairment, CYP2D6 poor metabolizers, recent dose changes, or concurrent use of MAOIs or triptans.
High fever, agitation, muscle rigidity, rapid heartbeat, blood pressure instability, confusion
Coordinate care. 14-day washout. Discuss depression treatment options compatible with MAO-B inhibitor therapy.
Discuss this combination with your prescriber. They may adjust timing, dosing, or switch to an alternative with fewer interaction risks. Never stop an antidepressant abruptly — taper under medical guidance.
Effexor (venlafaxine) must not be used with rasagiline (Azilect). The combination can cause potentially fatal serotonin syndrome.
Take Venlafaxine at the same time each day — most people prefer morning with breakfast. Rasagiline follows its prescribed schedule. SNRIs can affect blood pressure (both up and down), so monitor BP if combining with cardiovascular medications.
High fever, agitation, muscle rigidity, rapid heartbeat, blood pressure instability, confusion
Discuss this combination with your prescriber. They may adjust timing, dosing, or switch to an alternative with fewer interaction risks. Never stop an antidepressant abruptly — taper under medical guidance.
Coordinate care. 14-day washout. Discuss depression treatment options compatible with MAO-B inhibitor therapy.
Or browse the full interaction database (121,000+ pairs).