STOP — Contraindicated
FDA contraindication on rasagiline label. At least 14 days washout required between rasagiline and SSRI (5 weeks for fluoxetine).
Evidence level: STRONG
Rasagiline (Azilect, for Parkinson disease) combined with sertraline (Zoloft) can cause severe serotonin syndrome. The FDA label for rasagiline specifically says do not take with SSRIs.
Rasagiline is an irreversible MAO-B inhibitor; at any dose it has some MAO-A activity. Combined with SSRI, severe serotonin syndrome risk. FDA label for rasagiline contraindicates concurrent SSRI use.
Do not take these together. If switching medications, a washout period of at least 14 days is needed. Tell your neurologist about all antidepressants you take.
Take Sertraline at the same time each day — morning is most common to avoid sleep disruption. Rasagiline follows its prescribed schedule. SSRIs have a long half-life, so consistency matters more than the exact hour.
Higher risk for: elderly, those on multiple serotonergic drugs, people with liver impairment, CYP2D6 poor metabolizers, recent dose changes, or concurrent use of MAOIs or triptans.
Confusion, restlessness, high fever, tremor, muscle rigidity, rapid heartbeat, blood pressure spikes
Discuss antidepressant alternatives that may be safer with rasagiline (limited options — may need specialist input). Discuss 14-day washout requirement.
Discuss this combination with your prescriber. They may adjust timing, dosing, or switch to an alternative with fewer interaction risks. Never stop an antidepressant abruptly — taper under medical guidance.
Rasagiline (Azilect, for Parkinson disease) combined with sertraline (Zoloft) can cause severe serotonin syndrome. The FDA label for rasagiline specifically says do not take with SSRIs.
Take Sertraline at the same time each day — morning is most common to avoid sleep disruption. Rasagiline follows its prescribed schedule. SSRIs have a long half-life, so consistency matters more than the exact hour.
Confusion, restlessness, high fever, tremor, muscle rigidity, rapid heartbeat, blood pressure spikes
Discuss this combination with your prescriber. They may adjust timing, dosing, or switch to an alternative with fewer interaction risks. Never stop an antidepressant abruptly — taper under medical guidance.
Discuss antidepressant alternatives that may be safer with rasagiline (limited options — may need specialist input). Discuss 14-day washout requirement.
Or browse the full interaction database (121,000+ pairs).