STOP — Contraindicated
FDA contraindication on rasagiline label. 14-day washout required after stopping rasagiline before starting SNRI (or vice versa).
Evidence level: STRONG
Rasagiline (a Parkinson medication) combined with Cymbalta (duloxetine) can cause life-threatening serotonin syndrome. The FDA specifically says these must not be used together.
Rasagiline (irreversible MAO-B inhibitor) plus duloxetine (SNRI). FDA rasagiline label contraindicates SNRIs due to serotonin syndrome risk. Same mechanism as SSRI-MAO inhibitor interactions.
Do not take these together. A 14-day washout period is required when switching. Tell all your doctors about every medication you take.
Take Duloxetine at the same time each day — most people prefer morning with breakfast. Rasagiline follows its prescribed schedule. SNRIs can affect blood pressure (both up and down), so monitor BP if combining with cardiovascular medications.
Higher risk for: elderly, those on multiple serotonergic drugs, people with liver impairment, CYP2D6 poor metabolizers, recent dose changes, or concurrent use of MAOIs or triptans.
Confusion, agitation, high fever, muscle rigidity, rapid heartbeat, blood pressure instability, seizures
Coordinate between neurologist and psychiatrist. 14-day washout required. Discuss safer antidepressant options for Parkinson patients.
Discuss this combination with your prescriber. They may adjust timing, dosing, or switch to an alternative with fewer interaction risks. Never stop an antidepressant abruptly — taper under medical guidance.
Rasagiline (a Parkinson medication) combined with Cymbalta (duloxetine) can cause life-threatening serotonin syndrome. The FDA specifically says these must not be used together.
Take Duloxetine at the same time each day — most people prefer morning with breakfast. Rasagiline follows its prescribed schedule. SNRIs can affect blood pressure (both up and down), so monitor BP if combining with cardiovascular medications.
Confusion, agitation, high fever, muscle rigidity, rapid heartbeat, blood pressure instability, seizures
Discuss this combination with your prescriber. They may adjust timing, dosing, or switch to an alternative with fewer interaction risks. Never stop an antidepressant abruptly — taper under medical guidance.
Coordinate between neurologist and psychiatrist. 14-day washout required. Discuss safer antidepressant options for Parkinson patients.
Or browse the full interaction database (121,000+ pairs).