MAJOR — Use With Caution
Both drugs independently prolong QT. FDA fluoroquinolone label carries Black Box Warning mentioning QT prolongation. Avoid combination if possible.
Evidence level: STRONG
Levofloxacin (Levaquin) and amiodarone both prolong the QT interval of your heart. Using them together significantly increases your risk of a dangerous abnormal heart rhythm.
Additive QT prolongation: levofloxacin prolongs QT interval (FDA Black Box Warning on fluoroquinolones for QT risk). Combined with amiodarone QT prolongation, increased torsades de pointes risk.
If you take amiodarone and need an antibiotic, tell your doctor — many alternatives to levofloxacin exist that do not prolong QT. If levofloxacin is necessary, ECG monitoring is recommended.
Follow each medication's specific timing instructions. Levofloxacin — check if it requires an empty stomach or should be taken with food. Amiodarone follows its normal schedule. Complete the full antibiotic course as prescribed.
Higher risk for: those with liver or renal impairment, elderly, concurrent use of nephrotoxic or hepatotoxic drugs, history of C. difficile infection, or those on narrow therapeutic index medications (warfarin, digoxin).
Dizziness, fainting, palpitations, irregular rapid heartbeat, shortness of breath
Use non-fluoroquinolone antibiotics if possible. If levofloxacin is needed, check ECG and electrolytes. Correct any potassium or magnesium deficiency first.
Antibiotic interactions are often temporary (duration of treatment). Space supplements and probiotics 2-3 hours away from antibiotic doses. Ask your pharmacist if timing adjustments can reduce the interaction risk.
Levofloxacin (Levaquin) and amiodarone both prolong the QT interval of your heart. Using them together significantly increases your risk of a dangerous abnormal heart rhythm.
Follow each medication's specific timing instructions. Levofloxacin — check if it requires an empty stomach or should be taken with food. Amiodarone follows its normal schedule. Complete the full antibiotic course as prescribed.
Dizziness, fainting, palpitations, irregular rapid heartbeat, shortness of breath
Antibiotic interactions are often temporary (duration of treatment). Space supplements and probiotics 2-3 hours away from antibiotic doses. Ask your pharmacist if timing adjustments can reduce the interaction risk.
Use non-fluoroquinolone antibiotics if possible. If levofloxacin is needed, check ECG and electrolytes. Correct any potassium or magnesium deficiency first.
Or browse the full interaction database (121,000+ pairs).