STOP — Contraindicated
FDA contraindication — ziprasidone label specifically contraindicates use with drugs that prolong QT interval.
Evidence level: STRONG
Ziprasidone (Geodon) already carries a warning about heart rhythm problems (QT prolongation). Combining it with amiodarone, which also prolongs QT, creates a very high risk of life-threatening abnormal heart rhythms.
Ziprasidone prolongs QT interval (FDA Black Box Warning on ziprasidone label). Amiodarone also prolongs QT. Combined use is contraindicated due to high risk of torsades de pointes.
Do not use ziprasidone with amiodarone. Alternative antipsychotics that do not prolong QT should be used.
Take Amiodarone and Ziprasidone as prescribed by your healthcare provider. If both are taken daily, maintain consistent timing for each. Ask your pharmacist about optimal spacing — they have access to comprehensive interaction databases and can provide personalized timing guidance.
Higher risk for: elderly, those with liver or kidney impairment, polypharmacy (5+ medications), recent medication changes, or those with multiple chronic conditions. Consult your pharmacist for specific risk factors.
Dizziness, fainting, rapid irregular heartbeat, palpitations, seizures, sudden collapse
Use alternative antipsychotics (olanzapine, aripiprazole have less QT effect). If both are essential, continuous ECG monitoring required.
Discuss safer alternatives with your healthcare provider. They can recommend substitutions based on your specific health goals while minimizing interaction risks. Always bring a complete list of everything you take to your appointments.
Ziprasidone (Geodon) already carries a warning about heart rhythm problems (QT prolongation). Combining it with amiodarone, which also prolongs QT, creates a very high risk of life-threatening abnormal heart rhythms.
Take Amiodarone and Ziprasidone as prescribed by your healthcare provider. If both are taken daily, maintain consistent timing for each. Ask your pharmacist about optimal spacing — they have access to comprehensive interaction databases and can provide personalized timing guidance.
Dizziness, fainting, rapid irregular heartbeat, palpitations, seizures, sudden collapse
Discuss safer alternatives with your healthcare provider. They can recommend substitutions based on your specific health goals while minimizing interaction risks. Always bring a complete list of everything you take to your appointments.
Use alternative antipsychotics (olanzapine, aripiprazole have less QT effect). If both are essential, continuous ECG monitoring required.
Or browse the full interaction database (121,000+ pairs).