MAJOR — Use With Caution
FDA-documented QT risk. Moxifloxacin has the highest QT prolongation potential among fluoroquinolones. Avoid this combination.
Evidence level: STRONG
Moxifloxacin (Avelox) prolongs the QT interval more than other antibiotics in its class. Combining it with amiodarone (which already prolongs QT) is particularly dangerous for your heart rhythm.
Additive QT prolongation: moxifloxacin has the highest QT prolongation potential among fluoroquinolones. Combined with amiodarone, very high torsades de pointes risk. FDA labels warn.
Do not use moxifloxacin with amiodarone. Many alternative antibiotics are available. Always tell your doctor about your heart medication.
Follow each medication's specific timing instructions. Moxifloxacin — check if it requires an empty stomach or should be taken with food. Amiodarone follows its normal schedule. Complete the full antibiotic course as prescribed.
Higher risk for: those with liver or renal impairment, elderly, concurrent use of nephrotoxic or hepatotoxic drugs, history of C. difficile infection, or those on narrow therapeutic index medications (warfarin, digoxin).
Palpitations, dizziness, fainting, rapid irregular heartbeat, sudden cardiac arrest in extreme cases
Use alternative antibiotics that do not prolong QT. If no alternative exists, continuous cardiac monitoring is required.
Antibiotic interactions are often temporary (duration of treatment). Space supplements and probiotics 2-3 hours away from antibiotic doses. Ask your pharmacist if timing adjustments can reduce the interaction risk.
Moxifloxacin (Avelox) prolongs the QT interval more than other antibiotics in its class. Combining it with amiodarone (which already prolongs QT) is particularly dangerous for your heart rhythm.
Follow each medication's specific timing instructions. Moxifloxacin — check if it requires an empty stomach or should be taken with food. Amiodarone follows its normal schedule. Complete the full antibiotic course as prescribed.
Palpitations, dizziness, fainting, rapid irregular heartbeat, sudden cardiac arrest in extreme cases
Antibiotic interactions are often temporary (duration of treatment). Space supplements and probiotics 2-3 hours away from antibiotic doses. Ask your pharmacist if timing adjustments can reduce the interaction risk.
Use alternative antibiotics that do not prolong QT. If no alternative exists, continuous cardiac monitoring is required.
Or browse the full interaction database (121,000+ pairs).