# Shiso Herb **Canonical URL:** https://ingredients.hermeticasuperfoods.com/ingredients/shiso-herb **Data Source:** Hermetica Superfoods Ingredient Encyclopedia **Updated:** 2026-03-15 **Evidence Score:** 4 / 10 **Category:** Herb **Also Known As:** Perilla frutescens, Perilla, Beefsteak plant, Chinese basil, Purple mint ## Overview Shiso Herb (Perilla frutescens) is recognized for its diverse health benefits, largely attributed to key compounds like rosmarinic acid and luteolin. These compounds exert their effects through potent [antioxidant](/ingredients/condition/antioxidant), [anti-inflammatory](/ingredients/condition/inflammation), and [immunomodulatory](/ingredients/condition/immune-support) mechanisms, supporting various physiological functions. ## Health Benefits - Supports [immune function](/ingredients/condition/immune-support) by enhancing antimicrobial and [antioxidant activity](/ingredients/condition/antioxidant), bolstering cellular defense. - Promotes [cardiovascular](/ingredients/condition/heart-health) wellness by improving circulation and reducing arterial [inflammation](/ingredients/condition/inflammation) through polyphenols. - Aids in metabolic regulation by balancing blood sugar levels and supporting healthy lipid [metabolism](/ingredients/condition/weight-management). - Enhances [digestive health](/ingredients/condition/gut-health) by soothing gut inflammation and supporting enzymatic activity. - Provides [neuroprotective](/ingredients/condition/cognitive) benefits by reducing oxidative stress and supporting cognitive clarity. - Supports respiratory health with unique shiso-derived phytonutrients that enhance efficiency. ## Mechanism of Action Shiso Herb's primary mechanisms stem from compounds like rosmarinic acid, which neutralizes [reactive oxygen species](/ingredients/condition/antioxidant) through its potent antioxidant activity. It also modulates [inflammatory pathway](/ingredients/condition/inflammation)s, potentially by inhibiting pro-inflammatory mediators. Additionally, perillaldehyde and limonene contribute to its [antimicrobial](/ingredients/condition/immune-support) effects. ## Clinical Summary Clinical research on Shiso Herb, particularly focusing on compounds like rosmarinic acid, has explored its [antioxidant](/ingredients/condition/antioxidant) and [anti-inflammatory](/ingredients/condition/inflammation) properties in vitro and in animal models. Studies have investigated its potential benefits for [immune function](/ingredients/condition/immune-support), metabolic regulation, and [cardiovascular](/ingredients/condition/heart-health) support. While promising, human clinical trials with specific methodologies, sample sizes, and detailed outcomes are less frequently cited in the provided information, indicating a need for further robust investigation. ## Nutritional Profile - Rosmarinic Acid: Potent [antioxidant](/ingredients/condition/antioxidant) supporting immune and [cardiovascular health](/ingredients/condition/heart-health). - Polyphenols and Flavonoids: Provide [anti-inflammatory](/ingredients/condition/inflammation) and [neuroprotective](/ingredients/condition/cognitive) properties. - Anthocyanins: Contribute to antioxidant and anti-inflammatory effects. - Dietary Fiber and [Prebiotic](/ingredients/condition/gut-health)s: Support gut health and cholesterol-lowering effects. - Vitamins: A, C, and K, enhancing immune resilience, [collagen synthesis](/ingredients/condition/skin-health), and blood clot regulation. - Minerals: Calcium, magnesium, potassium, and iron, supporting electrolyte balance and muscle function. ## Dosage & Preparation - Traditional: Consumed as an herbal infusion, incorporated into medicinal tonics, or used fresh in culinary applications. - Modern Forms: Available as high-[antioxidant](/ingredients/condition/antioxidant) herb extracts, botanical powders, and nutraceuticals. - Dosage: 1–2 servings daily for optimal immune resilience, metabolic balance, and respiratory function, typically as an extract or tea. ## Safety & Drug Interactions No specific safety information, common side effects, drug interactions, or contraindications for Shiso Herb are detailed in the provided research. As with any herbal supplement, individuals should consult a healthcare professional before use, especially if pregnant, nursing, or taking medications. It is important to consider potential allergic reactions in sensitive individuals, although not explicitly mentioned in the available text. ## Scientific Research Research on Shiso Herb highlights its potent [antioxidant](/ingredients/condition/antioxidant), [anti-inflammatory](/ingredients/condition/inflammation), and [antimicrobial](/ingredients/condition/immune-support) effects. Studies have investigated rosmarinic acid for immune benefits, and polyphenols for metabolic regulation, [cardiovascular](/ingredients/condition/heart-health) support, and [gut microbiome](/ingredients/condition/gut-health) health. ## Historical & Cultural Context Historically revered in TCM, Kampo, and Korean herbal traditions, Shiso Herb was highly valued for respiratory protection, digestive balance, and immune resilience. Traditionally consumed in various forms, it symbolized vitality and healing in East Asian cultures. ## Synergistic Combinations Role: Herbal amplifier Intention: Immune & [Inflammation](/ingredients/condition/inflammation) | Cardio & Circulation Primary Pairings: - Ginger (Zingiber officinale) - Turmeric (Curcuma longa) - Camu Camu (Myrciaria dubia) - Moringa (Moringa oleifera) ## Frequently Asked Questions ### What is Shiso Herb? Shiso (Perilla frutescens) is a plant native to East Asia, extensively used in traditional medicine, particularly Kampo medicine, and is a common ingredient in Japanese cuisine. It is valued for its aromatic properties and medicinal applications. ### What are the primary active compounds in Shiso Herb? Shiso Herb contains key active compounds such as rosmarinic acid, luteolin, β-sitosterol, caffeic acid, and β-carotene. It also includes essential oils like perillaldehyde and limonene, all contributing to its therapeutic effects. ### How does Shiso Herb support immune function? Shiso Herb supports immune function through compounds like rosmarinic acid, which exhibits antimicrobial and immunomodulatory properties. These actions help bolster cellular defense and enhance the body's natural protective mechanisms against pathogens. ### Can Shiso Herb benefit cardiovascular health? Yes, Shiso Herb promotes cardiovascular wellness by improving circulation and reducing arterial inflammation. This benefit is largely attributed to its rich content of polyphenols, which contribute to vascular health and integrity. ### What are the antioxidant properties of Shiso Herb? Shiso Herb possesses potent antioxidant properties, primarily due to rosmarinic acid, which functions by countering reactive oxygen species. This helps protect cells from oxidative stress and damage, supporting overall cellular health. ### Is Shiso Herb safe to take during pregnancy and breastfeeding? While Shiso Herb is traditionally used in culinary applications and generally recognized as safe in food amounts, pregnant and breastfeeding women should consult with a healthcare provider before taking concentrated supplements. Limited clinical data exists on high-dose supplementation during these sensitive periods, so individualized medical guidance is recommended to ensure safety for both mother and infant. ### What is the recommended daily dosage of Shiso Herb supplements? Typical supplemental dosages range from 500–2,000 mg daily, depending on the form (extract, powder, or leaf) and individual health goals, though optimal dosing varies by product concentration. Starting with lower doses and gradually increasing under professional guidance helps assess tolerance and allows for personalized adjustment based on individual response. ### Does Shiso Herb interact with blood pressure or blood sugar medications? Shiso Herb may have mild blood sugar-lowering and blood pressure-regulating properties due to its polyphenol content, which could theoretically enhance the effects of antidiabetic or antihypertensive medications. Individuals taking medications for blood sugar control or hypertension should inform their healthcare provider before adding Shiso Herb supplements to avoid unintended interactions or dosing adjustments. ## References Sources: fdc.nal.usda.gov, pubmed.ncbi.nlm.nih.gov --- *Source: Hermetica Superfoods Ingredient Encyclopedia — https://ingredients.hermeticasuperfoods.com* *License: CC BY-NC-SA 4.0 — Attribution required. Commercial use: admin@hermeticasuperfoods.com*