Leaf & Herb · Herb

Shiso Herb

Provisional Moderate ScoreCompound

Hermetica Superfood Encyclopedia

Published March 15, 2026Last updated March 15, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Shiso Herb (Perilla frutescens) is recognized for its diverse health benefits, largely attributed to key compounds like rosmarinic acid and luteolin. These compounds exert their effects through potent antioxidant, anti-inflammatory, and immunomodulatory mechanisms, supporting various physiological functions.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryLeaf & Herb

GroupHerb

Public Score StatusProvisional Moderate

Primary KeywordShiso Herb benefits

Shiso Herb close-up macro showing natural texture and detail — rich in vii, ix, immune

Shiso Herb — botanical close-up

Reported Benefits (Provisional)

Supports immune function by enhancing antimicrobial and antioxidant activity, bolstering cellular defense.

Promotes cardiovascular wellness by improving circulation and reducing arterial inflammation through polyphenols.

Aids in metabolic regulation by balancing blood sugar levels and supporting healthy lipid metabolism.

Enhances digestive health by soothing gut inflammation and supporting enzymatic activity.

Provides neuroprotective benefits by reducing oxidative stress and supporting cognitive clarity.

Supports respiratory health with unique shiso-derived phytonutrients that enhance efficiency.

Origin & History

Natural habitat

Shiso (Perilla frutescens) is an aromatic herb native to East Asia, particularly Japan, China, and Korea, thriving in temperate climates. Traditionally revered in Traditional Chinese Medicine (TCM), Kampo, and Korean folk medicine, it is valued for its potent anti-inflammatory, immune-boosting, and digestive-supporting properties.

“Historically revered in TCM, Kampo, and Korean herbal traditions, Shiso Herb was highly valued for respiratory protection, digestive balance, and immune resilience. Traditionally consumed in various forms, it symbolized vitality and healing in East Asian cultures.”Traditional Medicine

Research Narrative (Provisional)

Research on Shiso Herb highlights its potent antioxidant, anti-inflammatory, and antimicrobial effects. Studies have investigated rosmarinic acid for immune benefits, and polyphenols for metabolic regulation, cardiovascular support, and gut microbiome health.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Rosmarinic Acid: Potent antioxidant supporting immune and cardiovascular health. - Polyphenols and Flavonoids: Provide anti-inflammatory and neuroprotective properties. - Anthocyanins: Contribute to antioxidant and anti-inflammatory effects. - Dietary Fiber and Prebiotics: Support gut health and cholesterol-lowering effects. - Vitamins: A, C, and K, enhancing immune resilience, collagen synthesis, and blood clot regulation. - Minerals: Calcium, magnesium, potassium, and iron, supporting electrolyte balance and muscle function.

Reported Mechanism (Provisional)

Mechanism of Action

Shiso Herb's primary mechanisms stem from compounds like rosmarinic acid, which neutralizes reactive oxygen species through its potent antioxidant activity. It also modulates inflammatory pathways, potentially by inhibiting pro-inflammatory mediators. Additionally, perillaldehyde and limonene contribute to its antimicrobial effects.

Clinical Narrative (Provisional)

Clinical research on Shiso Herb, particularly focusing on compounds like rosmarinic acid, has explored its antioxidant and anti-inflammatory properties in vitro and in animal models. Studies have investigated its potential benefits for immune function, metabolic regulation, and cardiovascular support. While promising, human clinical trials with specific methodologies, sample sizes, and detailed outcomes are less frequently cited in the provided information, indicating a need for further robust investigation.

Also Known As

Perilla frutescensPerillaBeefsteak plantChinese basilPurple mint

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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