Hermetica Superfood Encyclopedia
Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.
Review flags: AWAITING_SEMANTIC_VALIDATION
Setria is a patented form of reduced glutathione (L-γ-glutamyl-L-cysteinyl-glycine) that directly elevates cellular glutathione levels. It functions as the body's master antioxidant by neutralizing free radicals and supporting phase II detoxification pathways.
Reported Benefits (Provisional)
Origin & History
Setria is a branded form of reduced glutathione, a powerful antioxidant naturally produced in the body, manufactured through a fermentation process.
Research Narrative (Provisional)
Research, including clinical trials, supports Setria's role in enhancing antioxidant capacity and detoxification processes in the body.
Preparation & Dosage
Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.
Nutritional Profile
Setria (Reduced Glutathione) is a tripeptide composed of three amino acids: L-glutamate, L-cysteine, and glycine, with a molecular weight of 307.32 g/mol. As a purified bioactive compound rather than a whole food, it lacks conventional macronutrient or micronutrient profiles. Key compositional data: Protein-equivalent content approximately 85-95% pure reduced glutathione (GSH) per serving, typically dosed at 250-500mg per serving in supplement form. The active thiol (-SH) group on the cysteine residue is the primary bioactive site responsible for antioxidant and detoxification activity. Sulfur content is notably significant due to the cysteine component, contributing to its redox-active properties. Bioavailability notes: Setria is a patented, fermentation-derived form of glutathione clinically demonstrated to resist gastric degradation better than standard glutathione; oral bioavailability studies show blood GSH levels increase by approximately 30-35% at 250mg/day dosing over 4 weeks. Lymphocyte glutathione concentrations have been shown to increase by up to 35% with consistent supplementation. Unlike standard glutathione supplements, Setria has demonstrated measurable increases in whole-blood glutathione in randomized controlled trials, indicating superior absorption compared to non-patented forms. No caloric, fiber, or conventional mineral content of significance.
Reported Mechanism (Provisional)
Setria provides bioavailable reduced glutathione that directly increases intracellular GSH concentrations. It activates glutathione peroxidase and glutathione S-transferase enzymes, facilitating conjugation of toxins for elimination. The tripeptide also regenerates vitamins C and E while maintaining the reduced state of cysteine residues in proteins.
Clinical Narrative (Provisional)
Human studies demonstrate that Setria supplementation increases blood glutathione levels by 30% within 6 months at 500-1000mg daily doses. A randomized controlled trial with 54 adults showed significant improvements in oxidative stress markers and immune cell function. However, most clinical evidence comes from smaller studies lasting 6 months or less, with limited long-term safety data available.
Also Known As
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