Fruit

Mangosteen 10% Xanthones

Provisional Moderate Scorebotanical

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Mangosteen 10% xanthones is a standardized fruit extract containing alpha-mangostin and gamma-mangostin, potent bioactive compounds that provide antioxidant and anti-inflammatory effects. The xanthones work by neutralizing free radicals and inhibiting inflammatory enzymes like COX-2.

—

Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryFruit

GroupFruit

Public Score StatusProvisional Moderate

Primary Keywordmangosteen xanthones benefits

Mangosteen 10% Xanthones close-up macro showing natural texture and detail — rich in antioxidant, anti-inflammatory, anticancer

Mangosteen 10% Xanthones — botanical close-up

Reported Benefits (Provisional)

Provides potent antioxidant protection by neutralizing free radicals, reducing oxidative stress by 30%. - Supports immune health by enhancing T-cell function, boosting the body's defense against pathogens. - Reduces inflammation by inhibiting COX-2 enzymes, alleviating chronic pain and swelling. - Promotes heart health by reducing blood pressure, lowering the risk of cardiovascular diseases. - Supports digestive health by improving gut microbiota balance, enhancing nutrient absorption. - Enhances skin health by protecting against UV damage, reducing the risk of skin cancer. - Boosts energy levels by improving mitochondrial function, increasing cellular energy production.

Origin & History

Natural habitat

Mangosteen is a tropical fruit native to Southeast Asia, renowned for its sweet and tangy flavor. The fruit is particularly valued for its high xanthone content, a type of antioxidant.

“Mangosteen has been used in traditional medicine in Southeast Asia for centuries, often as a remedy for skin and digestive issues.”Traditional Medicine

Research Narrative (Provisional)

Research indicates mangosteen's potential in reducing oxidative stress and inflammation. Its xanthone content is under investigation for various health benefits.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Rich in xanthones, powerful antioxidants. - Contains vitamins C and B-complex. - Provides dietary fiber and essential minerals.

Reported Mechanism (Provisional)

Mechanism of Action

Alpha-mangostin and gamma-mangostin scavenge reactive oxygen species by donating electrons to neutralize free radicals. These xanthones selectively inhibit cyclooxygenase-2 (COX-2) enzymes while sparing COX-1, reducing inflammatory prostaglandin production. The compounds also modulate nuclear factor-kappa B (NF-κB) signaling pathways to suppress inflammatory gene expression.

Clinical Narrative (Provisional)

Human studies on mangosteen xanthones are limited, with most evidence from in vitro and animal research. One small clinical trial with 60 participants showed 30% reduction in oxidative stress markers after 30 days of supplementation. Animal studies demonstrate significant anti-inflammatory effects, but large-scale human trials are needed. The evidence for immune enhancement comes primarily from laboratory studies showing improved T-cell proliferation.

Also Known As

Garcinia mangostanaPurple mangosteenQueen of fruitsMangisManggisMangkhutSeerMangoustanier

Browse All Ingredients More Fruit About the Encyclopedia

These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

From the Hermetica Research Desk

Research updates — and 25% off your first order

Join our list for source-aware wellness education, review-state updates, and product news — and unlock 25% off your first Hermetica order. Educational content is not medical advice. No spam, unsubscribe anytime.

Educational content only — not medical advice.