Magnesium L-Threonate (Magtein) — Hermetica Encyclopedia
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Magnesium L-Threonate (Magtein)

Provisional Strong Scorevitamin

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By Hermetica Editorial Team
Published Last updated Methodology · Editorial policy · Report an error
Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Magnesium L-threonate is a patented form of magnesium bound to L-threonic acid that uniquely crosses the blood-brain barrier to increase brain magnesium levels by 15%. It enhances synaptic plasticity and NMDA receptor function, specifically supporting memory formation and cognitive performance.

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Screened PMID Records
1
Reported Benefits
Pending
Synergy Review
At a Glance
CategoryVitamin & Mineral
GroupMineral
Public Score StatusProvisional Strong
Primary Keywordmagnesium L-threonate benefits
Magnesium L-Threonate close-up macro showing natural texture and detail — rich in neuroprotective, cognitive enhancer, mineral supplement
Magnesium L-Threonate (Magtein) — botanical close-up

Reported Benefits (Provisional)

Supports cognitive function by enhancing synaptic plasticity, crucial for learning and memory. This enhancement can lead to improved problem-solving skills and information retention. - Enhances brain health by crossing the blood-brain barrier, a unique feature of Magnesium L-Threonate. This ability allows for direct support of neuronal health and function. - Reduces anxiety and stress by modulating neurotransmitter activity. This modulation can lead to a calmer mind and improved mood. - Improves sleep quality by regulating melatonin production. Better sleep can enhance overall well-being and daytime alertness. - Supports bone health by aiding in calcium absorption. Enhanced calcium uptake can lead to stronger bones and reduced fracture risk. - Boosts energy levels by participating in ATP production, the body's main energy currency. Increased ATP can lead to greater stamina and vitality. - Enhances cardiovascular health by maintaining healthy blood pressure levels. This regulation can reduce the risk of heart disease.

Origin & History

Magnesium L-Threonate growing in natural environment — natural habitat
Natural habitat

Magnesium L-Threonate, known as Magtein, is a chelated form of magnesium developed to enhance cognitive function. It is synthesized through the bonding of magnesium with threonic acid.

“Magnesium has been used for centuries for its calming effects, with Magtein developed more recently to target cognitive health specifically.”Traditional Medicine

Research Narrative (Provisional)

Animal studies and emerging human trials suggest Magtein's efficacy in enhancing cognitive function and brain health. Preliminary evidence supports its role in stress reduction.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Chelated form of magnesium. - Easily crosses the blood-brain barrier. - Essential for neurological and bone health.

Reported Mechanism (Provisional)

Mechanism of Action

Magnesium L-threonate utilizes L-threonic acid as a transport mechanism to cross the blood-brain barrier, increasing cerebrospinal fluid magnesium concentrations by approximately 15%. Once in the brain, magnesium acts as a cofactor for NMDA receptors and enhances long-term potentiation (LTP), the cellular basis of learning and memory. The compound specifically modulates presynaptic neurotransmitter release and postsynaptic receptor sensitivity at glutamatergic synapses.

Clinical Narrative (Provisional)

A randomized controlled trial with 44 adults aged 50-70 showed that 2g daily of magnesium L-threonate for 12 weeks improved cognitive performance equivalent to reversing brain aging by 9 years. Animal studies demonstrate enhanced spatial memory and increased synaptic density in hippocampal neurons. However, human clinical evidence remains limited with only one major published trial, though results showed statistically significant improvements in multiple cognitive assessments. Additional larger-scale studies are needed to confirm long-term efficacy and optimal dosing protocols.

Also Known As

Magnesium bis(L-threonate)MagteinMagnesium threonateL-threonic acid magnesium saltMg-L-threonateCognitive magnesiumBrain magnesium
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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.
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