Vitamin & Mineral · Mineral

Iron Bisglycinate

Provisional Strong Scorevitamin

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Iron bisglycinate is a chelated form of iron bound to two glycine amino acids, offering superior bioavailability compared to traditional iron salts. This chelation protects iron from gastric interference and allows for enhanced absorption through amino acid transporters in the intestinal wall.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryVitamin & Mineral

GroupMineral

Public Score StatusProvisional Strong

Primary Keywordiron bisglycinate benefits

Iron Bisglycinate — botanical close-up

Reported Benefits (Provisional)

Supports the production of red blood cells by enhancing hemoglobin synthesis

This support can prevent anemia and improve oxygen transport in the body. - Enhances energy levels by facilitating oxygen delivery to muscles and tissues. Better oxygenation can lead to increased stamina and reduced fatigue. - Supports cognitive function by improving oxygen supply to the brain. Enhanced brain oxygenation can lead to better focus and mental clarity. - Boosts immune function by supporting the proliferation of immune cells. A stronger immune system can better protect against infections. - Reduces oxidative stress by participating in antioxidant enzyme production. This reduction can lower the risk of chronic diseases. - Supports healthy pregnancy by preventing iron deficiency anemia, crucial for fetal development. Adequate iron levels can lead to healthier pregnancy outcomes. - Enhances athletic performance by improving endurance and recovery. Better performance can lead to more effective workouts and fitness gains.

Origin & History

Natural habitat

Iron bisglycinate is a chelated form of iron, where iron is bound to the amino acid glycine. This form is created through a process that enhances the bioavailability and absorption of iron, making it a preferred choice in dietary supplements.

“Iron has been used since ancient times to treat anemia and fatigue. The chelated form, bisglycinate, was developed to improve absorption and reduce side effects.”Traditional Medicine

Research Narrative (Provisional)

Randomized controlled trials have shown that iron bisglycinate is effective in increasing hemoglobin levels and improving iron status with fewer side effects compared to other forms of iron.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Provides elemental iron, crucial for oxygen transport in the blood. - Highly bioavailable form, ensuring effective absorption. - Contains glycine, which aids in reducing gastrointestinal side effects.

Reported Mechanism (Provisional)

Mechanism of Action

Iron bisglycinate bypasses the divalent metal transporter (DMT1) pathway used by inorganic iron forms, instead utilizing peptide transporters like PEPT1 for absorption. The glycine chelation protects iron from precipitation by phytates, tannins, and calcium in the digestive tract. Once absorbed, iron is incorporated into hemoglobin synthesis and cellular energy production through cytochrome oxidase enzymes.

Clinical Narrative (Provisional)

Comparative studies show iron bisglycinate demonstrates 2.3-4.6 times higher bioavailability than iron sulfate in healthy adults. Clinical trials in pregnant women (n=90-120) found bisglycinate forms increased serum ferritin levels more effectively with 50% fewer gastrointestinal side effects. Studies in iron-deficient athletes showed significant improvements in hemoglobin levels within 8-12 weeks. Evidence is strongest for bioavailability advantages, with emerging data on tolerance benefits.

Also Known As

Ferrous bisglycinateIron glycinate chelateChelated ironFerrous glycinateIron amino acid chelateBisglycinated ironIron(II) bisglycinate

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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