Hermetica Superfood Encyclopedia
Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.
Review flags: AWAITING_SEMANTIC_VALIDATION
Little Hogweed (Portulaca oleracea) contains alpha-linolenic acid and flavonoids that upregulate antioxidant enzymes like superoxide dismutase and catalase while reducing lipid peroxidation markers. Specific compounds like portulacerebroside A induce cancer cell apoptosis via p38 MAPK and JNK mitochondrial pathways with demonstrated IC₅₀ values of 1.6 μg/mL against gastric cancer cells.
Reported Benefits (Provisional)
Origin & History
Little Hogweed (Portulaca oleracea), also known as Purslane, is a succulent annual herb native to India and the Middle East, now widespread globally. It is highly valued in functional nutrition for its exceptional omega-3 fatty acid content, antioxidants, and diverse micronutrients.
Research Narrative (Provisional)
Extensive scientific studies, including in vitro, animal, and some human trials, validate Portulaca oleracea's rich omega-3 fatty acid content, potent antioxidant capacity, and anti-inflammatory effects. Research supports its benefits for cardiovascular health, blood sugar regulation, and immune resilience.
Preparation & Dosage
Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.
Nutritional Profile
- Fatty Acids: Omega-3 Fatty Acids (ALA) (cardiovascular, cognitive health) - Vitamins: A, C, E, B-complex vitamins - Minerals: Magnesium, Potassium, Calcium, Iron - Phytochemicals: Beta-carotene, Glutathione, Betalains (antioxidant protection) - Macronutrients: Dietary Fiber
Reported Mechanism (Provisional)
Alpha-linolenic acid and flavonoids like kaempferol and rutin upregulate superoxide dismutase, catalase, and glutathione peroxidase while reducing malondialdehyde levels. Portulacerebroside A triggers apoptosis in cancer cells through p38 MAPK and JNK mitochondrial pathways. Polysaccharides stimulate CD4⁺ cells, phagocytes, and CD14⁺ monocytes while modulating Th1/Th2 cytokine balance.
Clinical Narrative (Provisional)
Evidence comes primarily from in vitro and animal studies rather than human clinical trials. Mouse studies at 50-100 mg/kg showed significant antioxidant enzyme upregulation and reduced brain lipid peroxidation. Cancer cell studies demonstrated potent cytotoxicity with IC₅₀ values ranging from 1.6 μg/mL against gastric cells to 21.76-37.20 μmol/L against lung cancer cells. Human clinical data validating these preclinical findings is currently lacking.
Also Known As
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