Fruit · Leaf/Green

Lebanese Grape Leaves

Provisional Moderate ScoreCompound

Hermetica Superfood Encyclopedia

Published March 15, 2026Last updated March 15, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Lebanese grape leaves (*Vitis vinifera*) are rich in polyphenols like quercetin and resveratrol, conferring significant antioxidant and anti-inflammatory properties. These compounds scavenge free radicals and modulate inflammatory responses, contributing to their traditional health-supporting roles.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryFruit

GroupLeaf/Green

Public Score StatusProvisional Moderate

Primary Keywordlebanese grape leaves benefits

Lebanese Grape Leaves close-up macro showing natural texture and detail — rich in vii, ix, digestive

Lebanese Grape Leaves — botanical close-up

Reported Benefits (Provisional)

Supports digestive health by providing dietary fiber and soothing properties

Reduces oxidative stress with a high concentration of polyphenols and flavonoids.

Modulates inflammatory responses, offering systemic anti-inflammatory benefits

Aids in detoxification processes, contributing to overall metabolic health

Promotes skin health by neutralizing free radicals and supporting cellular integrity.

Enhances immune function through its vitamin K and antioxidant content

Origin & History

Natural habitat

Lebanese Grape Leaves (Vitis vinifera) are native to Lebanon and widely cultivated across the Mediterranean region, thriving in warm, temperate climates. They are valued in functional nutrition for their rich antioxidant profile and traditional use in digestive support.

“Lebanese Grape Leaves have been a cherished culinary delicacy and natural remedy in Lebanese culture for centuries. They are traditionally used to support digestion, detoxify the body, and nourish the skin, reflecting their deep integration into Mediterranean culinary and medicinal practices.”Traditional Medicine

Research Narrative (Provisional)

Scientific studies document the digestive, detoxifying, and skin-nourishing benefits of grape leaves (Vitis vinifera), primarily attributed to their rich antioxidant and anti-inflammatory compounds. Research supports their role in traditional medicinal applications.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Dietary Fiber: Supports digestive regularity. - Vitamin K: Essential for blood clotting and bone health. - Calcium, Magnesium: Key minerals for bone density, muscle function, and nerve transmission. - Polyphenols, Flavonoids: Potent antioxidants that reduce inflammation and support immune function.

Reported Mechanism (Provisional)

Mechanism of Action

Lebanese grape leaves are rich in bioactive polyphenols such as quercetin, resveratrol, and caffeic acid. These compounds exert antioxidant effects by scavenging DPPH and hydroxyl radicals, thereby reducing oxidative stress. Furthermore, they modulate inflammatory responses, evidenced by a reduction in pro-inflammatory markers like IL-8, and demonstrate potential antiproliferative effects in vitro through apoptosis modulation (e.g., activating Bax and reducing Bcl-2).

Clinical Narrative (Provisional)

Scientific investigations, primarily in vitro studies, have explored the pharmacological activities of Lebanese grape leaf extracts. These studies indicate significant antioxidant and anti-inflammatory potential attributed to their rich polyphenol content. Research on cancer cell lines (e.g., HepG2, MCF-7) suggests antiproliferative effects through the modulation of apoptotic pathways, although these findings require further validation in preclinical and human trials. Currently, human clinical trials specifically on Lebanese grape leaves are limited in the provided research.

Also Known As

Vitis viniferaGrape leavesVine leavesDolma leaves

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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