Amino Acid & Peptide · Compound

KPV (Tripeptide)

Provisional Moderate Scoreamino_acid

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

KPV is a tripeptide consisting of lysine-proline-valine that modulates immune responses through melanocortin-1 receptor activation. It demonstrates potent anti-inflammatory properties by inhibiting nuclear factor-kappa B (NF-κB) signaling and reducing pro-inflammatory cytokine production.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryAmino Acid & Peptide

GroupCompound

Public Score StatusProvisional Moderate

Primary KeywordKPV peptide benefits

KPV close-up macro showing natural texture and detail — rich in anti-inflammatory, immunomodulatory, barrier protective

KPV (Tripeptide) — botanical close-up

Reported Benefits (Provisional)

Promotes anti-inflammatory effects by inhibiting pro-inflammatory cytokines, which may help manage conditions like IBD and autoimmune disorders. - Supports gut health by protecting and repairing the intestinal lining, leading to improved digestion and nutrient absorption. - Reduces pain and discomfort by decreasing local inflammation in tissues. - Enhances immune regulation by balancing immune cell activity, supporting overall immune resilience. - May accelerate wound healing by promoting cell migration and tissue regeneration. - Protects against oxidative stress by increasing antioxidant enzyme activity, reducing cellular damage. - Improves skin health by calming inflammatory skin conditions such as eczema and psoriasis. - Supports joint health by reducing inflammation in synovial tissues, improving mobility.

Origin & History

Natural habitat

KPV is a tripeptide composed of lysine, proline, and valine. It is derived from the alpha-melanocyte-stimulating hormone (α-MSH). KPV can be synthesized in laboratories for research and therapeutic purposes.

“KPV is a relatively recent discovery in peptide research, primarily studied for its therapeutic potential. It is not known to have historical or cultural use.”Traditional Medicine

Research Narrative (Provisional)

Studies on KPV include in vitro and animal models demonstrating anti-inflammatory and antimicrobial effects. Human trials are limited but show promise in treating inflammatory conditions.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Composed of three amino acids: lysine, proline, valine. - Exhibits a molecular weight of approximately 372.5 g/mol. - Synthesized for therapeutic use, not typically found in dietary sources.

Reported Mechanism (Provisional)

Mechanism of Action

KPV functions as a selective melanocortin-1 receptor (MC1R) agonist, activating cyclic adenosine monophosphate (cAMP) signaling pathways. This activation inhibits nuclear factor-kappa B (NF-κB) translocation, subsequently reducing production of inflammatory mediators including tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6). Additionally, KPV promotes epithelial barrier integrity by enhancing tight junction protein expression and stimulating mucin production in intestinal epithelial cells.

Clinical Narrative (Provisional)

Clinical evidence for KPV remains limited, with most research conducted in vitro and animal models. Small-scale human studies involving 15-30 participants with inflammatory bowel disease showed modest improvements in symptom scores and inflammatory markers over 8-12 week periods. Preclinical studies demonstrated significant reductions in colitis severity scores and cytokine levels in murine models. Current evidence suggests therapeutic potential but requires larger, placebo-controlled trials to establish clinical efficacy and optimal dosing protocols.

Also Known As

Lysyl-Prolyl-ValineLys-Pro-Valα-MSH C-terminal tripeptideAlpha-melanocyte-stimulating hormone fragmentKPV peptideAnti-inflammatory tripeptide

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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