Hermetica Superfood Encyclopedia
Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.
Review flags: AWAITING_SEMANTIC_VALIDATION
Forest Mango (Mangifera indica) contains potent bioactive compounds including mangiferin (4.2-169 mg/100g) and quercetin that exhibit antioxidant activity with IC50 values of 13.37 µg/ml for radical scavenging. These xanthone glycosides and flavonoids modulate inflammatory pathways by inhibiting TNF-α, NO, and PGE2 production in macrophages while demonstrating reducing power of 10,172.59 µmol FeSO4·7H2O/g.
Reported Benefits (Provisional)
Origin & History
Forest Mango (Irvingia gabonensis), also known as African Mango or Dika Nut, is a fruit-bearing tree native to the tropical lowland rainforests and riverine ecosystems of West and Central Africa. Its seeds are particularly valued in functional nutrition for their unique fat-binding compounds and metabolic benefits.
Research Narrative (Provisional)
Clinical trials and systematic reviews have demonstrated Forest Mango seed extract (IGOB131) significantly impacts metabolic parameters, including weight management, blood glucose, and lipid profiles. Research supports its role in promoting satiety and reducing inflammation.
Preparation & Dosage
Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.
Nutritional Profile
- Soluble fiber - Vitamin C - Beta-carotene - Iron - Calcium - Flavonoids - Ellagic acid - IGOB131 (unique fat-binding compound from the seed)
Reported Mechanism (Provisional)
Mangiferin, the primary xanthone glycoside, inhibits pro-inflammatory mediators TNF-α, nitric oxide, and PGE2 in RAW264.7 macrophages while reducing myeloperoxidase activity. Quercetin and kaempferol (6.7-77.3 mg/100g) work synergistically to scavenge free radicals and inhibit Fe²⁺-induced lipid peroxidation with IC50 values of 1.44-1.88 mg/ml. These compounds also induce apoptosis in MCF-7 cancer cells through oxidative stress mechanisms.
Clinical Narrative (Provisional)
Clinical evidence remains limited, with only one human study using Vimang bark extract (10 mM mangiferin) showing reduced thiobarbituric acid-reactive substances to 14.67 mmol/L after 30 days. Most research consists of in vitro and animal studies demonstrating anti-inflammatory and antioxidant effects. No large-scale randomized controlled trials have established definitive therapeutic dosages or efficacy in human populations. Current evidence supports traditional uses but requires more robust clinical validation.
Also Known As
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