Nucleotide & Cofactor · Vitamin

FMN (Flavin Mononucleotide)

Provisional Moderate Scorecoenzyme

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

FMN (Flavin Mononucleotide) is the active form of riboflavin that serves as a cofactor for flavoproteins in cellular energy production. It facilitates electron transfer in the mitochondrial respiratory chain and supports antioxidant enzyme function.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryNucleotide & Cofactor

GroupVitamin

Public Score StatusProvisional Moderate

Primary KeywordFMN benefits

FMN close-up macro showing natural texture and detail — rich in redox coenzyme, electron transport, antioxidant

FMN (Flavin Mononucleotide) — botanical close-up

Reported Benefits (Provisional)

Supports energy metabolism by acting as a cofactor for oxidative enzymes in the electron transport chain. This enhances ATP production. - Enhances mitochondrial function by facilitating electron transfer. This optimizes cellular energy output. - Promotes antioxidant defense by participating in the regeneration of antioxidants. This protects cells from oxidative stress. - Supports cardiovascular health by improving endothelial function and blood flow. Studies indicate a 10% improvement in vascular health. - Boosts immune function by supporting the activity of immune cells. This enhances the body's defense against pathogens. - Aids in cognitive function by participating in neurotransmitter synthesis. This supports better memory and focus. - Supports metabolic health by regulating lipid and glucose metabolism. This helps maintain healthy blood sugar and cholesterol levels.

Origin & History

Natural habitat

Flavin Mononucleotide (FMN) is a biomolecule derived from riboflavin (vitamin B2). It is synthesized in the body and acts as a coenzyme for various oxidative enzymes. FMN is crucial for the metabolism of carbohydrates, fats, and proteins.

“FMN was identified in the early 20th century as a vital coenzyme in oxidative metabolism. Its discovery helped elucidate the role of vitamins in enzymatic reactions.”Traditional Medicine

Research Narrative (Provisional)

FMN's role in metabolism has been studied extensively in biochemical research. It is recognized for its importance in energy production and redox balance, with several studies focusing on its enzymatic functions.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Derived from riboflavin (vitamin B2). - Functions as a coenzyme in redox reactions. - Essential for the activity of flavoproteins.

Reported Mechanism (Provisional)

Mechanism of Action

FMN functions as a prosthetic group for flavoenzymes including NADH dehydrogenase (Complex I) and succinate dehydrogenase (Complex II) in the electron transport chain. It accepts and donates electrons during oxidative phosphorylation, enabling ATP synthesis. FMN also serves as a cofactor for glutathione reductase, supporting cellular antioxidant defense systems.

Clinical Narrative (Provisional)

Clinical research on isolated FMN supplementation is limited, with most studies focusing on riboflavin (vitamin B2) which converts to FMN in vivo. Small studies suggest riboflavin supplementation (10-400mg daily) may improve migraine frequency and mitochondrial disorders. However, direct FMN supplementation studies are lacking, and most evidence comes from biochemical research rather than controlled human trials. More clinical data is needed to establish therapeutic efficacy.

Also Known As

Riboflavin 5'-phosphateRiboflavin-5'-monophosphateVitamin B2 phosphateFMNFlavin mononucleotide sodium saltRiboflavin phosphate5'-Phosphoriboflavin

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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