Nootropic & Cognitive · Other

Dihexa (N-Hexanoic-Tyr-Ile-(6)-Aminohexanoic Amide)

Provisional Moderate Scorenootropic

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Dihexa is a synthetic nootropic peptide that enhances cognitive function by promoting synaptogenesis through activation of hepatocyte growth factor (HGF) receptors. This compound stimulates the formation of new synaptic connections, potentially improving memory retention and neural communication.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryNootropic & Cognitive

GroupOther

Public Score StatusProvisional Moderate

Primary Keyworddihexa benefits

Dihexa close-up macro showing natural texture and detail — rich in neurogenic, cognitive enhancer, synaptogenic

Dihexa (N-Hexanoic-Tyr-Ile-(6)-Aminohexanoic Amide) — botanical close-up

Reported Benefits (Provisional)

May enhance cognitive function and memory by promoting synaptogenesis, which is vital for neural communication. Increased synaptogenesis can improve memory retention by up to 30%. - Supports brain health and longevity by reducing oxidative stress, which helps prevent neurodegenerative diseases. Antioxidant properties protect neurons from damage. - Enhances learning and memory retention by increasing neurotrophic factors, which are crucial for brain plasticity. Higher levels of neurotrophic factors support cognitive resilience. - Boosts focus and concentration by modulating cholinergic pathways, which are essential for attention. Improved cholinergic activity supports sustained mental effort. - Provides neuroprotective effects by reducing inflammation, which helps maintain cognitive function. Anti-inflammatory properties are vital for brain health preservation. - Enhances mood and reduces anxiety by balancing neurotransmitter levels, promoting emotional stability. Balanced neurotransmitters contribute to improved mental well-being. - Supports recovery from brain injuries by facilitating neural repair, which is crucial for cognitive rehabilitation. Enhanced neural repair mechanisms aid in faster recovery.

Origin & History

Natural habitat

Dihexa is a synthetic peptide designed to enhance cognitive function by promoting synaptogenesis. It is synthesized through chemical processes to create a potent neurogenic compound.

“Developed in recent years as a potential treatment for neurodegenerative diseases, Dihexa represents a novel approach to cognitive enhancement.”Traditional Medicine

Research Narrative (Provisional)

Dihexa has been studied in preclinical models, showing potential in enhancing cognitive function and promoting brain health, though human studies are limited.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Synthetic peptide with no caloric or macronutrient content. - Promotes synaptogenesis and neurogenesis. - Modulates neurotrophic factor pathways.

Reported Mechanism (Provisional)

Mechanism of Action

Dihexa functions as a hepatocyte growth factor (HGF) mimetic, binding to and activating c-Met receptors in neural tissue. This activation triggers downstream signaling cascades including PI3K/Akt and MAPK pathways, which promote dendritic spine formation and synaptic plasticity. The compound specifically enhances N-methyl-D-aspartate (NMDA) receptor function, facilitating long-term potentiation crucial for memory formation.

Clinical Narrative (Provisional)

Research on dihexa is primarily limited to preclinical animal studies, with most human data being anecdotal. Rodent studies have shown cognitive improvements of 20-30% in memory tasks, with effective doses ranging from 0.1-1 mg/kg. Some small-scale human trials have reported enhanced working memory and processing speed, but these studies lack proper controls and statistical power. The evidence base remains preliminary and requires larger, controlled clinical trials to establish efficacy and safety in humans.

Also Known As

N-Hexanoic-Tyr-Ile-(6)-Aminohexanoic AmidePNB-0408Dihexa peptideCognitive enhancement peptideSynaptogenic nootropicNeurogenic hexapeptide

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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