Amino Acid & Peptide · Compound

Anserine

Provisional Moderate Scoreamino_acid

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Anserine is a dipeptide composed of beta-alanine and 1-methylhistidine that acts as a potent antioxidant and neuroprotectant. It primarily functions by chelating metal ions and scavenging reactive oxygen species, particularly protecting brain tissue from oxidative damage.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryAmino Acid & Peptide

GroupCompound

Public Score StatusProvisional Moderate

Primary Keywordanserine benefits

Anserine close-up macro showing natural texture and detail — rich in neuroprotective, antioxidant, cognitive enhancer

Anserine — botanical close-up

Reported Benefits (Provisional)

Supports cognitive function and brain health by protecting neurons from oxidative stress and inflammation. - Acts as a potent antioxidant, scavenging free radicals and reducing cellular damage in the brain. - Enhances memory retention and learning capacity by modulating neurotransmitter activity. - Promotes muscle endurance and reduces fatigue by buffering lactic acid during intense exercise. - May help regulate blood pressure by supporting vascular health and nitric oxide production. - Supports kidney health by reducing oxidative damage in renal tissues. - Contributes to healthy aging by protecting DNA and cellular structures from oxidative injury. - May aid in mood regulation by influencing brain chemistry and reducing neuroinflammation.

Origin & History

Natural habitat

Anserine is a dipeptide composed of beta-alanine and histidine, found predominantly in the skeletal muscles and brain of animals. It is extracted from animal sources like chicken and fish.

“Anserine has been recognized for its presence in animal tissues and its potential health benefits, traditionally consumed through diets rich in poultry and fish.”Traditional Medicine

Research Narrative (Provisional)

Emerging evidence from animal studies and preliminary human trials suggests anserine's role in cognitive enhancement and muscle performance. More research is needed to confirm these effects in humans.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Contains beta-alanine and histidine. - High antioxidant potential. - Found in animal muscle tissues.

Reported Mechanism (Provisional)

Mechanism of Action

Anserine functions through its imidazole ring structure, which chelates pro-oxidant metals like copper and zinc while directly scavenging hydroxyl radicals and singlet oxygen. It modulates NMDA receptor activity and inhibits advanced glycation end product formation, protecting neuronal membranes from lipid peroxidation. The compound also influences acetylcholine and dopamine neurotransmitter systems through its methylhistidine component.

Clinical Narrative (Provisional)

Human studies on anserine are limited, with most evidence derived from animal models and in vitro research. A small Japanese study (n=39) showed 1000mg daily anserine supplementation improved cognitive scores in elderly subjects over 12 weeks. Rodent studies demonstrate neuroprotective effects at doses equivalent to 500-2000mg daily in humans. More robust clinical trials are needed to establish definitive cognitive benefits in healthy and impaired populations.

Also Known As

β-alanyl-1-methylhistidineN-beta-alanyl-1-methylhistidineAnserine dipeptide1-Methylhistidine-beta-alanineCarnosine analogMuscle dipeptide

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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