# Akarakarabha (Anacyclus pyrethrum) **Canonical URL:** https://ingredients.hermeticasuperfoods.com/ingredients/akarakarabha **Data Source:** Hermetica Superfoods Ingredient Encyclopedia **Updated:** 2026-03-27 **Evidence Score:** 4 / 10 **Category:** Ayurveda **Also Known As:** Anacyclus pyrethrum, Pellitory, Pellitory-of-Spain, Mount Atlas Daisy, Spanish Chamomile, Pyrethrum Root, Akarkarabha, Akallaka, Spanish Pellitory ## Overview Anacyclus pyrethrum is an Ayurvedic herb containing bioactive compounds like pellitorine and anacyclin that may support sexual function and reduce inflammation. The plant works primarily through its alkaloids which can stimulate circulation and modulate [inflammatory pathway](/ingredients/condition/inflammation)s. ## Health Benefits • May support sexual function - traditionally used for Klaibya (sexual dysfunction) in Ayurveda (evidence quality: traditional use only) • May help reduce [inflammation](/ingredients/condition/inflammation) - traditionally indicated for Sotha (inflammation) in Ayurvedic medicine (evidence quality: traditional use only) • May improve digestive function - used for Agnimandhya (weak [digestion](/ingredients/condition/gut-health)) in traditional practice (evidence quality: traditional use only) • May support management of Vata disorders - traditionally used for Vata vyadhi in Ayurveda (evidence quality: traditional use only) • Contains bioactive compounds with potential analgesic properties - referenced in phytochemical analyses (evidence quality: preliminary) ## Mechanism of Action Anacyclus pyrethrum contains pellitorine, anacyclin, and other N-alkylamides that may enhance nitric oxide production and improve blood circulation. These compounds potentially modulate inflammatory pathways by inhibiting [pro-inflammatory cytokine](/ingredients/condition/inflammation)s like TNF-α and IL-6. The alkaloids may also influence [neurotransmitter activity](/ingredients/condition/cognitive) and hormonal pathways related to sexual function. ## Clinical Summary Most evidence for Anacyclus pyrethrum comes from traditional Ayurvedic texts rather than modern clinical trials. A few small animal studies have suggested potential aphrodisiac and [anti-inflammatory](/ingredients/condition/inflammation) effects, but sample sizes were limited (typically 6-8 animals per group). Human clinical data is extremely limited, with no large-scale randomized controlled trials available. Current evidence is insufficient to make definitive health claims about efficacy. ## Nutritional Profile Akarakarabha (Anacyclus pyrethrum) is a medicinal root used in small therapeutic doses rather than as a food ingredient, so macronutrient profiling is limited. Key bioactive compounds include: Alkylamides (pellitorine, anacyclin, hydroxy-alpha-sanshool) at approximately 1-2% of dry root weight - these are the primary pungent and bioactive constituents responsible for local anesthetic and sialagogue effects; Pyrethrin alkaloids and isobutylamides (~0.5-1% dry weight); Essential oils including inulin, traces of volatile terpenes and sesquiterpenes; Flavonoids including apigenin and luteolin glycosides at trace levels (~0.1-0.3%); Phenolic compounds including caffeic acid derivatives at low concentrations; Inulin-type polysaccharides in root tissue (~5-10% dry weight), contributing [prebiotic](/ingredients/condition/gut-health) fiber activity. Mineral content includes moderate calcium (~180 mg/100g dry root), potassium (~400 mg/100g), and trace iron and zinc. Crude protein is approximately 8-12% dry weight with limited bioavailability data. The alkylamides show good lipid-soluble bioavailability and are readily absorbed through oral mucosa - contributing to the characteristic tingling/numbing sensation. Most nutritional data is derived from phytochemical studies on dried root powder; standardized nutritional profiling data remains sparse in peer-reviewed literature. ## Dosage & Preparation Traditional Ayurvedic dosage for Akarkarabha root powder is 0.5 to 1 gram. Standardized extract dosages and concentration ranges for different formulations are not available in the current research. Consult a healthcare provider before starting any new supplement. ## Safety & Drug Interactions Anacyclus pyrethrum may cause gastrointestinal irritation, mouth tingling, or allergic reactions in sensitive individuals. It may interact with [blood pressure](/ingredients/condition/heart-health) medications due to its potential circulatory effects and could theoretically enhance the effects of phosphodiesterase inhibitors. Safety during pregnancy and breastfeeding is unknown and should be avoided. Individuals with cardiovascular conditions should consult healthcare providers before use. ## Scientific Research The provided research dossier explicitly states that no specific human clinical trials, randomized controlled trials (RCTs), or meta-analyses with PubMed PMIDs were found in the search results. While sources mention research investigating analgesic, [anti-inflammatory](/ingredients/condition/inflammation), and healing properties of plant extracts, specific clinical trial data, outcomes, and PMID citations are not available. ## Historical & Cultural Context Anacyclus pyrethrum has been used in Ayurvedic medicine as a traditional remedy, characterized as having Katu (pungent) taste with Ruksha (dry) and Teekshna (hot) qualities. The plant has also been used in North African and Mediterranean traditional medicine systems, though specific historical details and duration of use are not detailed in available sources. ## Synergistic Combinations Ashwagandha, Mucuna pruriens, Tribulus terrestris, Safed musli, Gokshura ## Frequently Asked Questions ### What is the active compound in Anacyclus pyrethrum? The primary bioactive compounds are pellitorine and anacyclin, which are N-alkylamides responsible for the plant's therapeutic effects. These alkaloids contribute to its traditional use for sexual dysfunction and inflammation. ### How much Anacyclus pyrethrum should I take daily? Traditional Ayurvedic texts suggest 1-3 grams of root powder daily, but no standardized clinical dosing exists. Most modern supplements contain 200-500mg of extract, though optimal dosing requires more research. ### Can Anacyclus pyrethrum help with erectile dysfunction? Traditional Ayurvedic medicine uses it for sexual dysfunction, and some animal studies suggest potential benefits. However, no human clinical trials have specifically tested its effects on erectile dysfunction. ### Is Anacyclus pyrethrum safe with blood pressure medications? It may interact with blood pressure medications due to its potential effects on circulation and nitric oxide pathways. Consult a healthcare provider before combining it with cardiovascular medications. ### What are the side effects of Anacyclus pyrethrum? Common side effects include mouth tingling, gastrointestinal irritation, and potential allergic reactions. Some users report mild digestive upset or oral numbness when consuming the raw root. ### Is Anacyclus pyrethrum safe during pregnancy and breastfeeding? Anacyclus pyrethrum is traditionally used as a reproductive tonic in Ayurveda, but safety data specifically for pregnancy and breastfeeding is limited. It is generally recommended to avoid this ingredient during pregnancy and lactation due to insufficient safety evidence, and consultation with a healthcare provider is advised before use in these populations. ### What is the most effective form of Anacyclus pyrethrum — root powder, extract, or capsule? Anacyclus pyrethrum is traditionally used as a dried root powder or decoction in Ayurvedic practice, which allows for direct use of the whole plant material. Standardized extracts and capsules may offer convenience, but bioavailability and efficacy differences between forms have not been rigorously compared in clinical research. ### What does scientific research show about Anacyclus pyrethrum's effectiveness? Most evidence for Anacyclus pyrethrum comes from traditional Ayurvedic use spanning centuries rather than modern clinical trials. Limited laboratory and animal studies suggest potential anti-inflammatory and reproductive benefits, but high-quality human clinical trials are needed to confirm efficacy and establish evidence-based dosing recommendations. --- *Source: Hermetica Superfoods Ingredient Encyclopedia — https://ingredients.hermeticasuperfoods.com* *License: CC BY-NC-SA 4.0 — Attribution required. Commercial use: admin@hermeticasuperfoods.com*