MAJOR — Use With Caution
FDA aripiprazole label — reduce dose 50% with strong CYP2D6 inhibitors.
Evidence level: STRONG
Paxil can increase Abilify levels significantly. The FDA recommends reducing the Abilify dose by half when taking it with Paxil.
Paroxetine is the most potent CYP2D6 inhibitor. FDA aripiprazole label recommends 50% dose reduction with strong CYP2D6 inhibitors.
Your Abilify dose should be reduced by half while taking Paxil. Tell all your prescribers about both medications.
Take Paroxetine at the same time each day — morning is most common to avoid sleep disruption. Aripiprazole follows its prescribed schedule. SSRIs have a long half-life, so consistency matters more than the exact hour.
Higher risk for: elderly, those on multiple serotonergic drugs, people with liver impairment, CYP2D6 poor metabolizers, recent dose changes, or concurrent use of MAOIs or triptans.
Excessive sedation, restlessness, tremor, dizziness
Reduce aripiprazole dose by 50%. Monitor for both increased side effects and therapeutic response at lower dose.
Discuss this combination with your prescriber. They may adjust timing, dosing, or switch to an alternative with fewer interaction risks. Never stop an antidepressant abruptly — taper under medical guidance.
Paxil can increase Abilify levels significantly. The FDA recommends reducing the Abilify dose by half when taking it with Paxil.
Take Paroxetine at the same time each day — morning is most common to avoid sleep disruption. Aripiprazole follows its prescribed schedule. SSRIs have a long half-life, so consistency matters more than the exact hour.
Excessive sedation, restlessness, tremor, dizziness
Discuss this combination with your prescriber. They may adjust timing, dosing, or switch to an alternative with fewer interaction risks. Never stop an antidepressant abruptly — taper under medical guidance.
Reduce aripiprazole dose by 50%. Monitor for both increased side effects and therapeutic response at lower dose.
Or browse the full interaction database (121,000+ pairs).