MODERATE — Monitor Closely
🟡 MODERATE — CBD may significantly increase Paroxetine levels.
Evidence level: MODERATE
CBD can significantly increase paroxetine levels since paroxetine relies heavily on CYP2D6 for metabolism.
CBD inhibits CYP2D6 (paroxetine's primary pathway) and CYP3A4, increasing paroxetine levels. Paroxetine also inhibits CYP2D6.
Use caution — paroxetine is heavily dependent on CYP2D6. Start CBD at very low doses and monitor closely for increased side effects.
Take Paroxetine at the same time each day as prescribed. CBD Oil can be taken at any convenient time — morning with breakfast is most common. Some botanicals (St. John's Wort especially) have serotonergic activity and must NOT be combined with SSRIs. If you notice increased drowsiness or agitation, shift the botanical to a different time or discuss discontinuation with your prescriber.
CYP2D6 poor metabolizers, elderly
Increased sedation, nausea, sexual side effects, serotonin syndrome symptoms
Discuss with psychiatrist, especially if experiencing increased side effects
Consider talking to your doctor about adjusting your antidepressant dose rather than adding CBD Oil. Safer supplement options for mood support include magnesium glycinate, omega-3 fish oil, or vitamin D3 — all with strong evidence and minimal drug interactions.
CBD can significantly increase paroxetine levels since paroxetine relies heavily on CYP2D6 for metabolism.
Take Paroxetine at the same time each day as prescribed. CBD Oil can be taken at any convenient time — morning with breakfast is most common. Some botanicals (St. John's Wort especially) have serotonergic activity and must NOT be combined with SSRIs. If you notice increased drowsiness or agitation, shift the botanical to a different time or discuss discontinuation with your prescriber.
Increased sedation, nausea, sexual side effects, serotonin syndrome symptoms
Consider talking to your doctor about adjusting your antidepressant dose rather than adding CBD Oil. Safer supplement options for mood support include magnesium glycinate, omega-3 fish oil, or vitamin D3 — all with strong evidence and minimal drug interactions.
Discuss with psychiatrist, especially if experiencing increased side effects
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