Trametes Versicolor Extract (PSK/PSP) — Hermetica Encyclopedia
Mushroom · Mushroom/Fungi

Trametes Versicolor Extract (PSK/PSP)

Provisional Strong Scorebotanical

Hermetica Superfood Encyclopedia

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Trametes versicolor extract contains bioactive polysaccharides PSK (polysaccharide-K) and PSP (polysaccharide-peptide) that stimulate immune cell activity. These compounds enhance natural killer cell function and T-cell response while supporting gut microbiome balance.

Screened PMID Records
1
Reported Benefits
Pending
Synergy Review
At a Glance
CategoryMushroom
GroupMushroom/Fungi
Public Score StatusProvisional Strong
Primary Keywordtrametes versicolor benefits
Trametes Versicolor Extract (PSK/PSP) — botanical
Trametes Versicolor Extract (PSK/PSP) — botanical close-up

Reported Benefits (Provisional)

Boosts immune system function by stimulating the production of white blood cells, enhancing the body's ability to fight infections. - Exhibits anti-cancer properties by inhibiting tumor growth and enhancing the efficacy of chemotherapy. - Supports gut health by promoting the growth of beneficial bacteria, improving digestion and nutrient absorption. - Reduces inflammation by modulating cytokine production, alleviating symptoms of chronic diseases. - Enhances liver function by promoting detoxification processes, protecting against liver damage. - Improves cardiovascular health by reducing cholesterol levels, lowering the risk of heart disease. - Supports respiratory health by reducing symptoms of respiratory infections, improving overall lung function.

Origin & History

Trametes Versicolor Extract (PSK/PSP) — origin
Natural habitat

Trametes Versicolor, also known as Turkey Tail, is a common polypore mushroom found worldwide on dead logs. It is harvested for its fruiting bodies and processed into extracts like PSK and PSP.

Trametes Versicolor has been used in traditional Chinese medicine for centuries, known as Yun Zhi, for its immune-supporting properties.Traditional Medicine

Research Narrative (Provisional)

Trametes Versicolor has been extensively studied, with numerous RCTs and meta-analyses supporting its immune-boosting and anti-cancer effects, particularly in cancer patients.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Rich in polysaccharides, especially PSK and PSP. - Contains beta-glucans and phenolic compounds. - Low in calories and fat.

Reported Mechanism (Provisional)

Mechanism of Action

PSK and PSP polysaccharides bind to toll-like receptors on immune cells, activating NF-κB and MAPK signaling pathways. This stimulates dendritic cell maturation, enhances natural killer cell cytotoxicity, and increases production of interferon-γ and interleukin-2. The compounds also modulate gut microbiota by promoting beneficial Bifidobacterium and Lactobacillus growth.

Clinical Narrative (Provisional)

Multiple randomized controlled trials involving over 8,000 cancer patients demonstrate PSK's ability to improve 5-year survival rates by 9-15% when combined with chemotherapy. Studies show 1-3g daily doses enhance immune markers including NK cell activity by 40-60% within 4-8 weeks. Gut health studies report increased beneficial bacteria populations and improved intestinal barrier function, though most trials are small-scale with 30-100 participants.

Also Known As

Coriolus versicolorTurkey TailYun ZhiCloud MushroomPSKPSPKawaratakePolyporus versicolor

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.
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