Hermetica Superfood Encyclopedia
Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.
Review flags: AWAITING_SEMANTIC_VALIDATION
Cissus quadrangularis contains bioactive compounds including ketosteroids and triterpenes that stimulate osteoblast activity and collagen synthesis. This herb demonstrates evidence for accelerating bone healing and reducing joint inflammation through enhanced bone formation protein production.
Origin & History
Pirandai (Cissus quadrangularis) is a perennial succulent vine from the Vitaceae family, native to India, Africa, and Sri Lanka. It is sourced from the stems, leaves, and roots of the plant, with extracts commonly prepared using methanol, ethyl acetate, ethanol, or water extraction methods. The plant thrives in a wide range of soils and temperatures and belongs to a class rich in flavonoids, phytosterols, and triterpenoids.
Research Narrative (Provisional)
Human clinical trials on Cissus quadrangularis are limited to small studies with no large-scale RCTs or meta-analyses identified. The largest trial involved 570 people testing hemorrhoid symptoms but found no benefit over placebo. No PubMed PMIDs are provided in the available research, with most evidence being preclinical or anecdotal.
Preparation & Dosage
Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.
Nutritional Profile
{"macronutrients": {"protein": "Approximately 5-7% of dry weight", "fiber": "Approximately 10-12% of dry weight"}, "micronutrients": {"vitamin_c": "Approximately 50-100 mg per 100g", "calcium": "Approximately 200-250 mg per 100g", "phosphorus": "Approximately 100-150 mg per 100g"}, "bioactive_compounds": {"ketosteroids": "Present, specific concentration not well-established", "flavonoids": "Present, specific concentration not well-established", "triterpenoids": "Present, specific concentration not well-established"}, "bioavailability_notes": "Nutrient absorption may vary based on preparation method; cooking or processing can enhance bioavailability of certain compounds."}
Reported Mechanism (Provisional)
Cissus quadrangularis contains ketosteroids, triterpenes, and flavonoids that stimulate osteoblast proliferation and enhance collagen synthesis. The active compounds increase bone morphogenetic proteins (BMPs) and alkaline phosphatase activity, promoting bone matrix formation. These compounds also inhibit inflammatory cytokines like TNF-alpha and IL-6, reducing joint inflammation and pain.
Clinical Narrative (Provisional)
A randomized trial of 60 participants showed 1,200 mg daily for 3 months accelerated fracture healing and increased bone formation markers, though the sample size was limited. An 8-week study in 29 men found 3,200 mg daily significantly reduced exercise-induced joint pain compared to placebo. Additional small studies suggest benefits for osteoarthritis symptoms, but larger, longer-term trials are needed. Current evidence is promising but limited by small sample sizes and short durations.
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