Hermetica Superfood Encyclopedia
Nimba (Azadirachta indica) is an Ayurvedic herb containing bioactive compounds like azadirachtin and nimbolide that exhibit antimicrobial and anti-inflammatory properties. The leaf extract demonstrates antibacterial activity against resistant pathogens and shows potential chemopreventive effects through modulation of cellular pathways.
Origin & History
Nimba (Azadirachta indica), commonly known as neem, is a tree native to the Indian subcontinent and Southeast Asia, belonging to the Meliaceae family. All parts of the tree—bark, leaves, seeds, roots, flowers, and fruit—are used medicinally, with extraction methods including ethanol extracts from leaves, decoctions from bark, and oils from seeds.
Scientific Research
The research dossier reveals a notable absence of human clinical trials, RCTs, or meta-analyses for Azadirachta indica. Current evidence is limited to preclinical and in vitro studies, including antibacterial testing against pathogens and anti-inflammatory effects in rat models at 200 mg/kg doses.
Preparation & Dosage
No clinically studied human dosage ranges are available. Animal studies used 200 mg/kg oral leaf extract for anti-inflammatory effects. Traditional preparations include leaf decoctions and pastes, but standardization criteria are not established. Consult a healthcare provider before starting any new supplement.
Nutritional Profile
{"macronutrients": {"fiber": "Approximately 3.6 g per 100 g of neem leaves", "protein": "Approximately 7.1 g per 100 g of neem leaves"}, "micronutrients": {"vitamins": {"Vitamin C": "About 24 mg per 100 g of neem leaves", "Vitamin E": "Trace amounts"}, "minerals": {"Calcium": "About 429 mg per 100 g of neem leaves", "Iron": "About 25.3 mg per 100 g of neem leaves", "Potassium": "About 875 mg per 100 g of neem leaves"}}, "bioactive_compounds": {"Azadirachtin": "Approximately 0.2% in neem seed kernels", "Nimbolide": "Trace amounts in leaves and seeds", "Quercetin": "Present in leaves, exact concentration varies"}, "bioavailability_notes": "The bioavailability of neem's bioactive compounds can be affected by factors such as preparation method and individual metabolism. Azadirachtin and nimbolide are more concentrated in seeds and leaves, respectively, and may require extraction for optimal absorption."}
How It Works
Nimba's primary bioactive compounds azadirachtin and nimbolide interfere with bacterial cell wall synthesis and disrupt protein function in pathogenic microorganisms. The anti-inflammatory effects appear to involve inhibition of pro-inflammatory cytokines and cyclooxygenase pathways. Chemopreventive properties likely involve modulation of phase II detoxification enzymes and inhibition of carcinogen-DNA adduct formation.
Clinical Evidence
In vitro studies demonstrate nimba leaf extract's antibacterial efficacy against Staphylococcus aureus and MRSA strains. Animal studies using 200 mg/kg doses showed significant anti-inflammatory effects in rodent models. Preliminary research in DMBA-induced rat carcinoma models suggests chemopreventive potential, though human clinical trials are lacking. Current evidence remains at the preclinical stage with limited human safety and efficacy data.
Safety & Interactions
Nimba may cause gastrointestinal upset, skin irritation, or allergic reactions in sensitive individuals. The herb may interact with immunosuppressive medications due to its immune-modulating properties and could potentially affect blood sugar levels. Pregnancy and breastfeeding safety has not been established, with traditional use suggesting avoidance during these periods. Hepatotoxicity has been reported with concentrated neem oil preparations, warranting caution with high-dose supplementation.
Also Known As
Frequently Asked Questions
What is the active compound in nimba?
What dosage of nimba leaf extract was used in studies?
Can nimba kill antibiotic-resistant bacteria?
Is nimba safe during pregnancy?
Does nimba interact with diabetes medications?
What is the difference between nimba leaf extract and nimba oil, and which form is more researched?
Does nimba have any established benefits or safety concerns for children?
How strong is the current evidence for nimba's effectiveness compared to conventional approaches for its traditional uses?
Conditions This May Help
This profile shares topic or mechanism tags with the health areas below. The links open provisional public-profile indexes; association does not establish a benefit or clinical recommendation.
Or jump to the curated Inflammation & Joint Health Profile Collection → a provisional discovery list with review-state disclosure.
Research updates — and 25% off your first order
Join our list for source-aware wellness education, review-state updates, and product news — and unlock 25% off your first Hermetica order. Educational content is not medical advice. No spam, unsubscribe anytime.