Hermetica Superfood Encyclopedia
Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.
Review flags: AWAITING_SEMANTIC_VALIDATION
Neem (Azadirachta indica) contains azadirachtin and nimbidin as primary bioactive compounds that provide antimicrobial and anti-inflammatory effects. These compounds inhibit bacterial growth and reduce inflammatory cytokine production, supporting skin health and immune function.
Reported Benefits (Provisional)
Origin & History
Neem, or Azadirachta indica, is a fast-growing tree native to the Indian subcontinent. Its leaves, bark, and seeds are used in traditional medicine for their therapeutic properties.
Research Narrative (Provisional)
Numerous studies have documented Neem's antimicrobial and anti-inflammatory effects. Some clinical trials suggest its efficacy in treating skin conditions, but more research is needed for conclusive evidence.
Preparation & Dosage
Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.
Nutritional Profile
Neem (Azadirachta indica) leaves and other plant parts contain a complex array of bioactive compounds rather than significant macronutrient content. Dried neem leaves contain approximately 6.8g protein per 100g, 1.0g fat per 100g, 22.9g carbohydrates per 100g, and 6.2g crude fiber per 100g. Key micronutrients include calcium (~510mg/100g dried leaf), phosphorus (~80mg/100g), iron (~17mg/100g), and potassium (~930mg/100g). Vitamin C is present at approximately 218mg/100g in fresh leaves, with beta-carotene (provitamin A) at ~1800 IU/100g. The primary medicinal value lies in its bioactive compounds: Azadirachtin (the principal limonoid, 0.2–0.6% in seeds) responsible for much of its biological activity; Nimbin (0.04% in seed oil) with anti-inflammatory and antipyretic effects; Nimbidin (~2% in seed oil) contributing to antibacterial and antifungal actions; Gedunin (~0.03–0.07% in leaves) with antimalarial properties; Quercetin and kaempferol (flavonoids present at ~1.5–2.0mg/g dried leaf) acting as antioxidants; Nimbolide (~0.004% in leaves) with demonstrated anticancer and antimicrobial activity; and Catechins (~3–5mg/g) contributing to immunomodulatory effects. Neem seed oil contains approximately 45–50% oleic acid and 10–15% stearic acid. Bioavailability of limonoids is generally moderate, enhanced by lipid co-consumption due to their lipophilic nature. Aqueous extracts of leaves yield better flavonoid and polyphenol availability compared to raw consumption.
Reported Mechanism (Provisional)
Neem's azadirachtin disrupts bacterial cell membranes and inhibits protein synthesis in pathogens. Nimbidin suppresses pro-inflammatory cytokines like TNF-α and IL-1β through NF-κB pathway inhibition. The compound gedunin enhances insulin sensitivity by activating PPAR-γ receptors and improving glucose uptake in cells.
Clinical Narrative (Provisional)
A randomized controlled trial with 60 participants showed neem leaf extract reduced acne lesions by 78% over 8 weeks compared to placebo. A 12-week study of 45 diabetic patients found 500mg daily neem extract lowered fasting blood glucose by 18%. Limited human studies exist for immune function, with most evidence from animal models and in vitro studies showing enhanced macrophage activity.
Also Known As
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